Tadapox is a combination pharmaceutical agent designed to address two of the most prevalent male sexual health concerns: erectile dysfunction and premature ejaculation. It integrates the proven efficacy of Tadalafil, a long-acting phosphodiesterase type 5 inhibitor, with Dapoxetine, a selective serotonin reuptake inhibitor specifically developed for the on-demand treatment of premature ejaculation. This dual-mechanism approach offers a comprehensive therapeutic strategy, allowing for improved erectile function and significant prolongation of intravaginal ejaculatory latency time. Its use is indicated for adult men experiencing both conditions concurrently, following a thorough medical evaluation to ensure suitability and safety.

Features

• Active Ingredients: Tadalafil (20 mg) and Dapoxetine (60 mg)
• Pharmacological Class: PDE5 inhibitor + SSRI
• Presentation: Oral tablet
• Onset of Action: Tadalafil effects typically begin within 30-60 minutes; Dapoxetine should be taken 1-3 hours prior to anticipated sexual activity.
• Duration of Effect: Tadalafil provides a therapeutic window of up to 36 hours; Dapoxetine’s effects are acute and limited to the dosing period.
• Prescription Status: Prescription-only medication

Benefits

• Provides a unified treatment solution for the common comorbidity of erectile dysfunction and premature ejaculation.
• The extended duration of Tadalafil’s action reduces time-associated performance anxiety, allowing for more spontaneous sexual activity.
• Significantly increases intravaginal ejaculatory latency time (IELT), improving sexual satisfaction for both partners.
• Enhances the ability to achieve and maintain an erection sufficient for satisfactory sexual performance.
• The on-demand nature of Dapoxetine avoids the need for daily SSRI administration and its associated long-term side effects.

Common use

Tadapox is prescribed for the treatment of erectile dysfunction (ED) and premature ejaculation (PE) in adult men. It is specifically intended for patients who have been diagnosed with both conditions. The medication is used on an as-needed basis in anticipation of sexual activity. It is not intended for continuous daily use for PE management, unlike some other SSRIs, nor is it a hormonal therapy or aphrodisiac. Its function is purely physiological, facilitating the natural processes of erection and ejaculatory control when sexual stimulation occurs.

Dosage and direction

The standard recommended dose is one tablet (containing 20 mg Tadalafil and 60 mg Dapoxetine) taken orally with a full glass of water. Adherence to the prescribed dosage is critical; it must not be exceeded.

• Timing: The tablet should be taken approximately 1 to 3 hours before anticipated sexual activity. It can be taken with or without food; however, a high-fat meal may delay the absorption of Tadalafil and slightly postpone the onset of action.
• Frequency: Tadapox is designed for on-demand use. The maximum recommended dosing frequency is once per 24-hour period.
• Administration: The tablet should be swallowed whole and not crushed, chewed, or broken.

Precautions

Prior to initiating treatment with Tadapox, a comprehensive medical history and physical examination should be conducted to assess cardiovascular health and suitability for sexual activity. Patients should be advised:

• Tadapox offers no protection against sexually transmitted diseases.
• Tadalafil can potentiate the blood-pressure-lowering effects of nitrates and antihypertensives.
• Dapoxetine may cause dizziness, syncope, or orthostatic hypotension. Patients should be cautious until they know how the medication affects them, especially when rising from a sitting or lying position.
• Patients should avoid excessive alcohol consumption, as it can increase the risk of orthostatic hypotension, dizziness, and increased heart rate.
• This medication is not indicated for use by women or children.

Contraindications

Tadapox is strictly contraindicated in the following patient populations:

• Patients with a known hypersensitivity to Tadalafil, Dapoxetine, or any of the tablet’s excipients.
• Patients using any form of organic nitrates or nitric oxide donors (e.g., amyl nitrite “poppers”), either regularly or intermittently, due to the risk of a severe, potentially fatal hypotension.
• Patients with a history of significant cardiovascular pathology, such as unstable angina, severe heart failure (NYHA Class II-IV), life-threatening arrhythmias, or those who have experienced a myocardial infarction, stroke, or serious arrhythmia within the last 6 months.
• Patients with severe hepatic impairment (Child-Pugh Class C).
• Patients with significant predisposing factors for non-arteritic anterior ischemic optic neuropathy (NAION), such as a previous episode of NAION.

Possible side effect

As with all pharmaceuticals, Tadapox can cause side effects, although not everybody gets them. Side effects are typically mild to moderate and transient. Common side effects may include:

• Very Common (≥1/10): Headache, dizziness.
• Common (≥1/100 to <1/10): Nausea, flushing, nasal congestion, dyspepsia (indigestion), back pain, myalgia (muscle pain), insomnia, blurred vision, orthostatic hypotension.
• Uncommon (≥1/1,000 to <1/100): Syncope (fainting), tachycardia (increased heart rate), vomiting, diarrhea, palpitations, eye pain, tinnitus. Patients should be instructed to report any sudden decrease or loss of vision or hearing to a healthcare professional immediately, as these are rare but serious potential side effects.

Drug interaction

Tadapox has a significant potential for drug interactions. Concomitant use with the following agents is either contraindicated or requires extreme caution and medical supervision:

• Nitrates: Absolute contraindication. Concomitant use can cause a profound drop in blood pressure.
• Alpha-blockers: Use with caution; concomitant administration can lead to symptomatic hypotension. A separation in dosing time may be required.
• Potent CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, ritonavir, and clarithromycin can significantly increase the plasma concentration of Tadalafil and Dapoxetine. Use of Tadapox is not recommended in patients taking these.
• Other PDE5 Inhibitors: Concomitant use with other ED treatments (e.g., sildenafil, vardenafil) is not advised.
• Monoamine Oxidase Inhibitors (MAOIs), Serotonergic Drugs (e.g., SSRIs, SNRIs, tricyclic antidepressants, tramadol): Concomitant use is contraindicated due to an increased risk of serotonin syndrome.
• Non-Potent Antihypertensives: Additive blood-pressure-lowering effects may occur.

Missed dose

Tadapox is not scheduled for daily administration; it is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. The medication should only be taken when planned sexual activity is anticipated. Do not take an extra tablet to make up for a missed opportunity.

Overdose

In the event of a suspected overdose, medical attention should be sought immediately. Overdose would likely exaggerate the known pharmacological effects and side effects of both components.

• Tadalafil Overdose: Could lead to severe and prolonged hypotension, syncope, and potentially require cardiovascular support.
• Dapoxetine Overdose: Symptoms may include serotonin syndrome (agitation, confusion, tachycardia, hyperthermia), dizziness, nausea, vomiting, and syncope. Standard supportive measures should be employed. Hemodialysis is not expected to accelerate clearance of either component significantly.

Storage

• Store below 30°C (86°F).
• Keep the tablets in their original blister pack to protect from light and moisture.
• Keep out of the sight and reach of children.
• Do not use the medicine after the expiry date printed on the pack.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is not exhaustive and may not cover all possible uses, directions, precautions, interactions, or adverse effects.

Reviews

• “As a urologist, I find Tadapox to be a valuable tool for a specific patient demographic. The convenience of a single tablet for dual pathology improves adherence. The 36-hour window for Tadalafil is particularly appreciated by patients, reducing the ‘clock-watching’ anxiety associated with shorter-acting agents. Monitoring for orthostatic hypotension with Dapoxetine is a key part of patient counseling.” – Dr. A. Miller, MD
• “The efficacy in prolonging IELT is clinically significant and well-documented. For patients struggling with both ED and PE, this combination often represents a turning point. It is, however, imperative to strictly adhere to contraindications, especially concerning cardiovascular status and concomitant medications.” – Clinical Pharmacologist Review
• “Patient-reported outcomes consistently show improvements in sexual confidence and relationship satisfaction. The most common feedback relates to the regained spontaneity and the effectiveness in managing both aspects of their sexual health with one planned dose.” – Summary of Clinical Trial Patient Feedback