Sildigra Softgel represents a significant advancement in the oral pharmacotherapy of erectile dysfunction (ED). This formulation utilizes Sildenafil Citrate, a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), delivered in a highly bioavailable softgel capsule. The softgel technology enhances the pharmacokinetic profile, potentially leading to more rapid onset of action and improved consistency in therapeutic effect compared to traditional tablet forms. It is indicated for the management of erectile dysfunction to improve erectile function and achieve successful sexual intercourse.

Features

• Active Pharmaceutical Ingredient: Sildenafil Citrate 100mg (or other strengths as prescribed).
• Pharmaceutical Form: Oral softgel capsule.
• Mechanism of Action: Selective inhibition of phosphodiesterase type 5 (PDE5).
• Enhanced Bioavailability: Softgel formulation for potentially improved absorption.
• Excipients: Includes gelatin, glycerin, purified water, and pharmaceutical-grade dyes.

Benefits

• Facilitates the achievement and maintenance of an erection sufficient for sexual activity upon sexual stimulation.
• The softgel formulation is designed for potentially faster absorption, which may lead to a reduced time to onset of action.
• Improved consistency in drug delivery may contribute to more predictable therapeutic outcomes.
• The easy-to-swallow form can enhance patient compliance, especially for those with difficulty swallowing tablets.
• Effective management of erectile dysfunction can contribute to improved self-confidence and sexual relationship satisfaction.

Common use

Sildigra Softgel is prescribed for the treatment of erectile dysfunction (ED) in adult men. It is used to overcome the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. Its use is contingent upon sexual stimulation; it does not result in an automatic erection. It is not indicated for use by women, children, or adolescents.

Dosage and direction

The recommended starting dose for most patients is one 50mg softgel, taken approximately 30-60 minutes before anticipated sexual activity. Based on efficacy and tolerability, the dose may be increased to a maximum recommended dose of 100mg or decreased to 25mg. Dosing should be limited to a maximum of one dose per 24-hour period. The softgel should be swallowed whole with a glass of water; it may be taken with or without food, though a high-fat meal may delay the time to onset of effect.

Precautions

• Prior to prescribing, a thorough medical history and physical examination should be conducted to diagnose ED, determine potential underlying causes, and identify appropriate treatment.
• Patients with cardiovascular disease: Sexual activity carries a potential cardiac risk. Sildigra Softgel should not be used in men for whom sexual activity is inadvisable due to their underlying cardiovascular status.
• Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie’s disease) or conditions that may predispose them to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia).
• Non-arteritic anterior ischemic optic neuropathy (NAION) has been reported post-marketing in temporal association with PDE5 inhibitor use. Use with caution in patients with a history of NAION.
• Sudden decrease or loss of hearing has been reported. Patients should seek immediate medical attention in the event of sudden hearing loss.
• This medication offers no protection against sexually transmitted diseases.

Contraindications

• Concomitant administration with any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors in any form.
• Concomitant use with guanylate cyclase stimulators, such as riociguat.
• Known hypersensitivity to Sildenafil Citrate or any of the excipients in the softgel formulation.
• Patients with a history of serious hypersensitivity reaction to Sildenafil.

Possible side effect

Like all medicines, Sildigra Softgel can cause side effects, although not everybody gets them. Common side effects are generally mild to moderate and transient. They include:

• Headache
• Flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Dizziness
• Visual disturbances (e.g., color tinge to vision, blurred vision, increased sensitivity to light)
• Back pain / myalgia Less common but more serious side effects require immediate medical attention:
• Priapism (a painful erection lasting more than 4 hours)
• Sudden loss of vision in one or both eyes
• Sudden decrease or loss of hearing
• Severe cardiovascular events (e.g., myocardial infarction, unstable angina, ventricular arrhythmia)

Drug interaction

• Nitrates: Concomitant use is contraindicated due to the risk of profound hypotension.
• Alpha-blockers: Concomitant use can lead to symptomatic hypotension. Dose adjustment or separation of administration may be required.
• Potent CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, ritonavir, and clarithromycin can significantly increase Sildenafil plasma concentrations. A maximum dose of 25mg within a 48-hour period is recommended with such inhibitors.
• Antihypertensives: Additive blood-pressure-lowering effects are possible.
• Other PDE5 Inhibitors: Concomitant use with other medications for erectile dysfunction is not recommended.

Missed dose

Sildigra Softgel is not intended for chronic daily dosing. It is taken on an as-needed basis prior to sexual activity. The concept of a “missed dose” does not apply. Do not take an extra dose to make up for a missed one.

Overdose

In cases of overdose, standard supportive measures should be adopted as required. Expected effects would be an extension of the drug’s vasodilatory properties, including severe hypotension. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly protein-bound and not significantly eliminated in the urine.

Storage

Store at room temperature (15°-30°C or 59°-86°F). Protect from light and moisture. Keep the bottle tightly closed. Keep out of the reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

“After struggling with ED for years and trying a tablet form of Sildenafil, my urologist suggested the softgel. The difference in onset time is noticeable for me. I feel more confident as the effects are more consistent.” – M.C., 58 “The softgel is much easier to swallow than a pill. I experienced the common flushing and a minor headache the first time, but it was manageable and hasn’t recurred. It has effectively restored my sexual function.” – J.T., 62 “As a healthcare professional, I appreciate the pharmacokinetic advantages of the softgel delivery system. It provides my patients with a reliable and effective option for managing their ED with a potentially improved profile.” – Dr. A. Reynolds