Zestril: Effective Blood Pressure Control and Heart Failure Management
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.76 | $45.58 (0%) | 🛒 Add to cart |
| 90 | $0.66 | $68.37 $59.34 (13%) | 🛒 Add to cart |
| 120 | $0.61 | $91.16 $73.10 (20%) | 🛒 Add to cart |
| 180 | $0.55 | $136.74 $99.76 (27%) | 🛒 Add to cart |
| 270 | $0.52 | $205.11 $140.18 (32%) | 🛒 Add to cart |
| 360 | $0.50
Best per pill | $273.48 $180.60 (34%) | 🛒 Add to cart |
| Product dosage: 2.5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 90 | $0.39 | $35.26 (0%) | 🛒 Add to cart |
| 120 | $0.34 | $47.01 $41.28 (12%) | 🛒 Add to cart |
| 180 | $0.31 | $70.52 $55.04 (22%) | 🛒 Add to cart |
| 270 | $0.28 | $105.78 $74.82 (29%) | 🛒 Add to cart |
| 360 | $0.26
Best per pill | $141.04 $94.60 (33%) | 🛒 Add to cart |
| Product dosage: 5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.73 | $43.86 (0%) | 🛒 Add to cart |
| 90 | $0.64 | $65.79 $57.62 (12%) | 🛒 Add to cart |
| 120 | $0.59 | $87.72 $70.52 (20%) | 🛒 Add to cart |
| 180 | $0.54 | $131.58 $96.32 (27%) | 🛒 Add to cart |
| 270 | $0.50 | $197.37 $135.02 (32%) | 🛒 Add to cart |
| 360 | $0.48
Best per pill | $263.16 $174.58 (34%) | 🛒 Add to cart |
Synonyms | |||
Zestril (lisinopril) is an angiotensin-converting enzyme (ACE) inhibitor prescribed for the management of hypertension, heart failure, and post-myocardial infarction care. As a cornerstone in cardiovascular therapeutics, it works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing the heart’s workload. Its proven efficacy in clinical trials and long-standing position in treatment guidelines make it a trusted option for physicians seeking to mitigate cardiovascular risk in appropriate patient populations. This medication requires a prescription and should be used under strict medical supervision to ensure optimal therapeutic outcomes and monitor for potential adverse effects.
Features
- Active pharmaceutical ingredient: Lisinopril
- Available in tablet formulations: 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg
- Standardized, bioequivalent formulation ensuring consistent pharmacokinetics
- Once-daily dosing regimen supporting patient adherence
- Demonstrated stability under recommended storage conditions
- Manufactured under current Good Manufacturing Practice (cGMP) standards
Benefits
- Effectively lowers systolic and diastolic blood pressure, reducing hypertension-related complications
- Decreases mortality in patients with congestive heart failure when used as part of comprehensive therapy
- Improves survival following acute myocardial infarction, particularly when initiated within 24 hours
- Provides renal protective effects in hypertensive patients with diabetes and proteinuria
- Reduces afterload on the heart, improving cardiac output and functional capacity
- Offers convenient once-daily dosing that supports long-term treatment adherence
Common use
Zestril is primarily indicated for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive agents. It is also approved for the management of heart failure to improve survival and reduce hospitalization, and is used in hemodynamically stable patients within 24 hours of acute myocardial infarction to improve survival. Additionally, it is prescribed for diabetic nephropathy in hypertensive patients with type 2 diabetes to slow the progression of renal disease. Off-label uses may include migraine prophylaxis and certain forms of scleroderma renal crisis, though these applications require careful specialist evaluation.
Dosage and direction
For hypertension: Initial dose typically ranges from 10-40 mg once daily, with maintenance doses adjusted based on blood pressure response. Maximum recommended daily dose is 80 mg. For heart failure: Initial dose is 5 mg once daily, titrated upward as tolerated to a target maintenance dose of 20-40 mg daily. Post-myocardial infarction: Initiate with 5 mg within 24 hours, followed by 5 mg after 24 hours, 10 mg after 48 hours, then maintenance at 10 mg daily. Renal impairment requires dosage adjustment based on creatinine clearance. Tablets should be swallowed whole with water, with or without food, though consistency in administration relative to meals is recommended.
Precautions
Monitor blood pressure and renal function regularly, especially during initiation and dosage adjustments. Assess serum potassium levels periodically due to risk of hyperkalemia. Use caution in patients with renal artery stenosis, as acute renal failure may occur. Avoid use during pregnancy due to potential fetal harm. Exercise caution in patients with collagen vascular disease or those receiving immunosuppressive therapy due to increased risk of neutropenia/agranulocytosis. Patients with heart failure may experience symptomatic hypotension; initiate therapy under close medical supervision. Angioedema may occur at any time during treatment, requiring immediate discontinuation.
Contraindications
History of angioedema related to previous ACE inhibitor treatment. Hypersensitivity to lisinopril or any component of the formulation. Concomitant use with aliskiren in patients with diabetes. Patients with hereditary or idiopathic angioedema. Second and third trimester of pregnancy. Bilateral renal artery stenosis or stenosis in a solitary kidney.
Possible side effect
Common: dizziness (6-12%), headache (5-8%), cough (up to 35% in some studies), fatigue (3-5%), nausea (2-5%). Less common: orthostatic hypotension, rash, impotence, hyperkalemia, taste disturbance. Serious but rare: angioedema (0.1-0.7%), neutropenia/agranulocytosis, hepatic failure, pancreatitis, renal impairment. The cough is typically dry, persistent, and resolves upon discontinuation. Most side effects are dose-dependent and may diminish with continued therapy or dosage adjustment.
Drug interaction
Potassium supplements, potassium-sparing diuretics, or salt substitutes containing potassium may increase risk of hyperkalemia. NSAIDs may reduce antihypertensive effect and increase risk of renal impairment. Diuretics may potentiate hypotensive effects, particularly with initial dosing. Lithium levels may increase due to reduced renal clearance. Oral hypoglycemics and insulin: enhanced hypoglycemic effect possible. Gold injections may cause nitritoid reactions. Dual blockade of the renin-angiotensin system with ARBs or aliskiren increases risks of hypotension, hyperkalemia, and renal impairment.
Missed dose
If a dose is missed, it should be taken as soon as remembered on the same day. If it is near the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed dose. Maintain consistent daily dosing for optimal blood pressure control. Patients should be educated on the importance of adherence while understanding proper management of occasional missed doses.
Overdose
Symptoms may include severe hypotension, bradycardia, circulatory shock, electrolyte disturbances, and renal failure. Management involves supportive care with volume expansion with normal saline for hypotension. Lisinopril is not effectively removed by hemodialysis due to extensive tissue binding. Bradycardia may require atropine administration. Monitor vital signs, electrolyte levels, and renal function closely. Angiotensin II infusion may be considered in severe cases under intensive care supervision.
Storage
Store at controlled room temperature (20-25°C or 68-77°F) with excursions permitted between 15-30°C (59-86°F). Protect from moisture and light. Keep container tightly closed. Do not store in bathroom or other areas with high humidity. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Properly discard any unused medication that is no longer needed.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Zestril is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Individual patient response may vary, and treatment decisions should be based on comprehensive medical evaluation. Always follow your healthcare provider’s instructions regarding dosage, administration, and monitoring. Report any adverse effects to your physician promptly. Never share prescription medications with others.
Reviews
Clinical studies demonstrate Zestril’s efficacy with significant blood pressure reduction observed in 70-80% of hypertensive patients. In heart failure trials, it reduced mortality by approximately 16% compared to placebo. Post-MI studies showed a 27% reduction in mortality at six weeks. Patient satisfaction surveys indicate good tolerability aside from the characteristic ACE inhibitor cough, which affects treatment continuation in approximately 5-15% of patients. Long-term follow-up studies confirm sustained efficacy and safety profile over years of treatment when appropriately monitored.