The Tiova Inhaler (Tiotropium Bromide) is a long-acting muscarinic antagonist (LAMA) inhaler prescribed for the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It functions by relaxing the muscles around the airways, leading to significantly improved breathing for up to 24 hours with a single dose. This medication is a cornerstone in the management of COPD, aimed at reducing exacerbation frequency, improving exercise tolerance, and enhancing overall quality of life. It is not indicated for the initial relief of acute bronchospasm.

Features

• Contains Tiotropium Bromide as the active pharmaceutical ingredient.
• Delivers a metered dose of 9 mcg per inhalation.
• Formulated as a dry powder inhaler (DPI) for direct lung delivery.
• Designed for once-daily dosing, supporting consistent therapeutic levels.
• Features a built-in dose counter to track remaining medication.
• Requires minimal patient coordination for effective administration.

Benefits

• Sustained 24-Hour Bronchodilation: Provides round-the-clock airway opening, reducing breathlessness both day and night.
• Reduces COPD Exacerbations: Long-term use is clinically proven to decrease the frequency and severity of symptom flare-ups.
• Improves Exercise Capacity: By facilitating easier breathing, it enables patients to engage in physical activity with less discomfort.
• Enhances Quality of Life: Consistent symptom control leads to greater independence and daily functioning.
• Convenient Dosing Regimen: Once-daily administration improves adherence compared to multiple-daily-dose therapies.

Common use

The Tiova Inhaler is indicated for the long-term, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD). It is used to manage symptoms such as wheezing, shortness of breath, and chronic coughing. It is not a rescue medication and should not be used to treat sudden attacks of breathlessness.

Dosage and direction

The recommended dosage for adults is the inhalation of the contents of one capsule once daily, at the same time each day, using the Tiova Inhaler device. The capsule must only be used with the designated inhaler and must not be swallowed. Instructions for use:

1. Open the dust cap and then the mouthpiece.
2. Place the capsule in the capsule chamber.
3. Close the mouthpiece firmly until a click is heard.
4. Hold the inhaler upright and press the piercing button completely once and release.
5. Breathe out fully away from the mouthpiece.
6. Place the mouthpiece between your lips and breathe in deeply and steadily at a rate sufficient to hear the capsule vibrate.
7. Hold your breath for as long as comfortable, then exhale away from the inhaler.
8. Repeat steps 5 and 6 to ensure the full dose is inhaled.
9. Open the mouthpiece and discard the empty capsule.

Precautions

• Inform your healthcare provider if you have a history of kidney problems, narrow-angle glaucoma, prostatic hyperplasia, or bladder neck obstruction.
• It may cause dizziness or blurred vision; do not drive or operate machinery until you know how it affects you.
• Immediate hypersensitivity reactions, including angioedema, may occur. Discontinue use and seek medical attention if symptoms appear.
• As with other inhaled medicines, Tiova may cause paradoxical bronchospasm (wheezing immediately after inhalation). If this occurs, discontinue use and use a fast-acting inhaler, then consult your physician.
• Be aware that this therapy treats the symptoms of COPD but does not alter the progressive nature of the disease.

Contraindications

Tiova Inhaler is contraindicated in patients with a known hypersensitivity to tiotropium bromide, atropine or its derivatives, such as ipratropium, or any other component of the product.

Possible side effect

Common side effects may include:

• Dry mouth
• Sinusitis
• Pharyngitis
• Constipation
• Increased heart rate (tachycardia)
• blurred vision
• Urinary retention Less common but serious side effects require immediate medical attention:
• Worsening of narrow-angle glaucoma (eye pain, blurred vision, visual halos)
• Worsening of urinary retention (difficulty urinating, painful urination)
• Severe allergic reactions (rash, hives, itching, swelling of the face/lips/tongue)

Drug interaction

• Concomitant use with other anticholinergic-containing drugs (e.g., ipratropium, aclidinium) is not recommended as it may potentiate adverse effects.
• Use caution when co-administering with drugs that also possess anticholinergic properties (e.g., some antidepressants, antihistamines, antipsychotics).
• Inform your doctor of all other medications you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Missed dose

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Overdose

An overdose may lead to an exacerbation of anticholinergic effects such as dry mouth, visual disturbance, tachycardia, and difficulty in urination. In severe cases, delirium, psychosis, and cardiac arrhythmias may occur. There is no specific antidote. Treatment should be supportive and symptomatic. Medical attention should be sought immediately.

Storage

• Store at room temperature (15°C - 30°C), protected from light and moisture.
• Keep the capsules in the blister pack and only remove immediately before use.
• Always keep the device dry.
• Keep out of reach of children and pets.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

“After being on Tiova for six months, my exacerbations have reduced dramatically. My morning routine is no longer defined by a struggle for breath. The once-daily dose is easy to remember and the inhaler is straightforward to use once you get the hang of it.” – John D., COPD patient.

“As a pulmonologist, I find Tiova to be a reliable first-line LAMA for my moderate to severe COPD patients. Its 24-hour efficacy provides stable baseline control, which is crucial for improving long-term outcomes and quality of life. The side effect profile is generally manageable for most.” – Dr. Eleanor R., Respiratory Specialist.