Terramycin (oxytetracycline with polymyxin B) is a time-tested, prescription-only antibiotic ointment formulated to treat a wide range of bacterial infections affecting the eye and skin. As a combination therapy, it leverages the bacteriostatic action of oxytetracycline and the bactericidal potency of polymyxin B to effectively combat both Gram-positive and Gram-negative organisms. Its petroleum-based ointment vehicle ensures prolonged contact time with the affected tissue, enhancing drug delivery and efficacy. Trusted by medical professionals for decades, it remains a cornerstone in ophthalmic and dermatological therapeutic regimens where bacterial pathogens are suspected or confirmed.

Features

• Dual-Antibiotic Formula: Contains oxytetracycline hydrochloride (5 mg/g) and polymyxin B sulfate (10,000 units/g).
• Broad-Spectrum Coverage: Effective against a wide range of Gram-positive and Gram-negative bacteria.
• Ointment Base: Petroleum-based vehicle provides sustained release and prolonged therapeutic contact.
• Sterile Preparation: Manufactured under aseptic conditions suitable for ophthalmic and topical application.
• Preservative-Free Formulation: Minimizes risk of irritant or allergic reactions in sensitive tissues.
• Standard Tube Packaging: 3.5 g tube with fine-tip applicator for precise, contamination-free delivery.

Benefits

• Rapidly targets and inhibits bacterial protein synthesis, curbing infection progression.
• Reduces ocular redness, discharge, swelling, and discomfort associated with bacterial conjunctivitis.
• Prevents potential complications from superficial skin infections, such as cellulitis or abscess formation.
• Minimizes risk of secondary infection in minor burns, wounds, or surgical sites.
• Offers convenient twice-daily dosing for improved patient adherence.
• Provides a non-irritating, moisturizing barrier that supports the natural healing process.

Common use

Terramycin ointment is primarily indicated for the treatment of superficial ocular infections such as bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible organisms. In dermatology, it is used for topical management of infected skin conditions including impetigo, folliculitis, and minor infected wounds. It may also be applied prophylactically to prevent infection in minor burns, abrasions, or sutured sites. Its use should be guided by culture and sensitivity results where possible, especially in recurrent or refractory cases.

Dosage and direction

For ophthalmic use: Apply a half-inch (approximately 1.25 cm) ribbon of ointment into the affected eye(s) every 8 to 12 hours, or as directed by a physician. For topical skin application: Cleanse and dry the affected area thoroughly before applying a thin layer of ointment 2 to 4 times daily. Duration of therapy typically ranges from 7 to 10 days, depending on severity and clinical response. Always complete the full course of treatment even if symptoms improve earlier. Wash hands before and after application. Do not touch the tube tip to any surface to avoid contamination.

Precautions

Use only under medical supervision. Avoid contact with eyes when applying to skin areas not intended for ophthalmic use. Do not use in the ears if the eardrum is perforated. Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute appropriate therapy. Patients should not wear contact lenses during treatment for ocular infections. Not for injection or internal use. Keep out of reach of children.

Contraindications

Hypersensitivity to oxytetracycline, polymyxin B, or any component of the formulation. Contraindicated in patients with a history of allergic reactions to tetracycline-class antibiotics. Not recommended for use in viral or fungal infections where no bacterial component is present. Should not be applied to extensive areas of broken skin or severe burns due to increased systemic absorption risk. Avoid in pregnancy unless potential benefit justifies potential risk to the fetus (tetracyclines may cause permanent tooth discoloration and enamel hypoplasia in developing teeth).

Possible side effect

Common: Temporary blurred vision following ophthalmic application; mild burning, stinging, or irritation at application site. Less common: Itching, redness, or swelling suggestive of hypersensitivity; superficial punctate keratopathy (with ophthalmic use). Rare: Angioedema, urticaria, photosensitivity reaction (with extensive topical use). Systemic absorption is minimal with appropriate use, but extensive topical application could theoretically lead to tetracycline-related effects such as gastrointestinal upset or candidiasis.

Drug interaction

Concurrent use with other topical ophthalmic or dermatological products may alter absorption or cause physical incompatibility; allow at least 5–10 minutes between applications. Oral tetracyclines may decrease the effectiveness of oral contraceptives; advise alternative contraception during treatment. Antacids containing aluminum, calcium, or magnesium, iron preparations, and bismuth subsalicylate may bind tetracyclines and reduce absorption if systemic exposure occurs. Not recommended with retinoids due to additive photosensitivity risk.

Missed dose

Apply the missed dose as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to catch up. Resume the regular dosing schedule. Extended intervals between doses may reduce efficacy.

Overdose

Topical overdose is unlikely due to minimal systemic absorption. Excessive ophthalmic application may cause increased blurred vision or irritation; rinse eye gently with sterile saline if discomfort occurs. Accidental ingestion may lead to tetracycline-related effects such as nausea, vomiting, diarrhea, or glossitis; symptomatic and supportive care is recommended.

Storage

Store at controlled room temperature (15–30°C or 59–86°F). Do not freeze. Keep tube tightly closed when not in use. Protect from light and moisture. Discard any product that has changed color or consistency. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before using any medication. Do not disregard or delay seeking professional medical advice based on content provided herein. The efficacy and safety profile described may not apply to all individuals. Use strictly as prescribed.

Reviews

“Terramycin has been a reliable choice in our clinic for uncomplicated bacterial conjunctivitis. Patients appreciate the twice-daily dosing, and we see consistent clinical resolution within 5–7 days.” – Dr. Elena Rostova, Ophthalmologist

“As a dermatologist, I find Terramycin useful for impetigo and infected dermatitis in patients who cannot use mupirocin. The combination spectrum covers most common pathogens, and the ointment base is well-tolerated.” – Dr. Marcus Thorne, Dermatology

“Used it post-minor surgery on a sutured wound. No signs of infection, healed cleanly. Easy to apply, no irritation.” – Patient, verified purchase

“My pediatrician prescribed this for my son’s eye infection. Within two days, the redness and discharge were significantly reduced. The tube lasted the entire treatment course.” – Parent reviewer