Skelaxin: Targeted Muscle Spasm Relief with Minimal Sedation
| Product dosage: 400mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $2.12 | $63.64 (0%) | 🛒 Add to cart |
| 60 | $1.68 | $127.28 $100.62 (21%) | 🛒 Add to cart |
| 90 | $1.52 | $190.92 $136.74 (28%) | 🛒 Add to cart |
| 120 | $1.45 | $254.56 $173.72 (32%) | 🛒 Add to cart |
| 180 | $1.37 | $381.84 $246.82 (35%) | 🛒 Add to cart |
| 270 | $1.33
Best per pill | $572.76 $358.62 (37%) | 🛒 Add to cart |
Synonyms | |||
Skelaxin (metaxalone) is a centrally acting skeletal muscle relaxant indicated for the treatment of acute, painful musculoskeletal conditions. It functions by depressing polysynaptic reflexes in the spinal cord and subcortical areas of the brain, leading to muscle relaxation without complete paralysis. Unlike many older agents in its class, Skelaxin demonstrates a favorable side effect profile with notably less sedation, making it a preferred choice for patients requiring functional alertness during treatment. Its efficacy in reducing muscle spasm and associated pain is well-documented in clinical settings, providing a valuable option in comprehensive pain management protocols.
Features
- Active ingredient: Metaxalone 800 mg
- Tablet formulation for oral administration
- Central nervous system depressant action
- Rapid onset of action within one hour
- Minimal cytochrome P450 metabolism
- Renal excretion as primary elimination pathway
Benefits
- Provides effective relief from acute musculoskeletal pain and discomfort
- Reduces muscle spasm without causing significant functional impairment
- Maintains patient alertness better than traditional muscle relaxants
- Supports faster return to normal activities through improved mobility
- Complements physical therapy regimens by reducing pain barriers
- Offers predictable pharmacokinetics with consistent dosing effects
Common use
Skelaxin is primarily prescribed for the adjunctive treatment of acute, painful musculoskeletal conditions characterized by muscle spasm. These typically include lower back pain, cervical strain, whiplash injuries, muscle strains, and other trauma-related muscular injuries. Physicians often prescribe it alongside rest, physical therapy, and other analgesics to create a comprehensive treatment approach. The medication is specifically indicated for short-term use, generally not exceeding two to three weeks, as most acute musculoskeletal conditions resolve within this timeframe.
Dosage and direction
The recommended adult dosage is one 800 mg tablet three to four times daily. Tablets should be taken whole with a full glass of water and may be administered with or without food, though taking with food may reduce potential gastrointestinal discomfort. Treatment duration should not exceed two to three weeks unless specifically directed by a healthcare provider. Dosage adjustment is generally not required for elderly patients with normal renal and hepatic function, but careful monitoring is advised. The medication should not be crushed or chewed as this may affect the release characteristics.
Precautions
Patients should be cautioned about operating machinery or driving until they know how Skelaxin affects them, as individual responses may vary. Those with impaired hepatic function should use Skelaxin with caution due to potential altered metabolism. Regular monitoring of liver function tests may be warranted during extended therapy. Dehydration may increase the risk of adverse effects, particularly dizziness; maintain adequate fluid intake during treatment. The medication may enhance the effects of alcohol and other CNS depressants, requiring appropriate lifestyle modifications during therapy.
Contraindications
Skelaxin is contraindicated in patients with known hypersensitivity to metaxalone or any components of the formulation. It should not be used in patients with significantly impaired renal or hepatic function. The medication is contraindicated in those with a tendency to drug-induced hemolytic anemia or other blood dyscrasias. Use is prohibited in patients with acute intermittent porphyria due to potential exacerbation of symptoms. The safety and effectiveness in children under 12 years of age have not been established.
Possible side effects
The most commonly reported adverse reactions include dizziness, drowsiness, headache, and nervousness, occurring in approximately 5-10% of patients. Gastrointestinal effects such as nausea, vomiting, and gastrointestinal upset may occur, particularly when taken without food. Less frequent side effects include hypersensitivity reactions, rash, and pruritus. Cases of hemolytic anemia, leukopenia, and hepatitis have been reported rarely. Patients should report any yellowing of skin or eyes, dark urine, or unusual tiredness, as these may indicate serious hepatic reactions.
Drug interaction
Skelaxin may potentiate the effects of alcohol, barbiturates, benzodiazepines, and other CNS depressants, requiring dosage adjustment of concomitant medications. While metaxalone has minimal cytochrome P450 interactions, caution is advised with strong CYP inhibitors or inducers. The medication may enhance the effects of opioid analgesics when used concurrently. MAO inhibitors may theoretically increase CNS effects, though clinical significance is uncertain. Always inform healthcare providers of all prescription and non-prescription medications being taken.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed administration. Maintaining consistent dosing intervals helps ensure stable therapeutic levels and optimal efficacy. If multiple doses are missed, contact a healthcare provider for guidance on resuming therapy.
Overdose
Symptoms of overdose may include exaggerated CNS depression, dizziness, drowsiness, nausea, and vomiting. In severe cases, respiratory depression and coma may occur. Management involves gastric lavage or activated charcoal if ingestion was recent, along with supportive measures including maintenance of adequate respiratory function. There is no specific antidote for metaxalone overdose. Hemodialysis is not expected to be beneficial due to the drug’s protein binding characteristics. Contact poison control center immediately for guidance.
Storage
Store at controlled room temperature between 20°C to 25°C (68°F to 77°F). Keep in original container with lid tightly closed to protect from moisture and light. Keep out of reach of children and pets. Do not store in bathroom areas where moisture levels may fluctuate. Properly discard any expired medication or medication no longer needed. Do not flush medications down the toilet or pour into drain unless specifically instructed to do so.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Individual patient responses may vary. Always consult with a qualified healthcare professional before starting, stopping, or changing any medication regimen. The complete prescribing information should be reviewed before administration. Not all possible uses, interactions, or adverse effects are included here.
Reviews
Clinical studies demonstrate Skelaxin’s efficacy in reducing muscle spasm and improving functional status. In comparative trials, patients reported significantly less sedation compared to other muscle relaxants while maintaining comparable efficacy in pain reduction. Many practitioners appreciate its favorable side effect profile, particularly for patients who need to remain alert during treatment. Long-term clinical experience supports its position as a well-tolerated option for acute musculoskeletal conditions when used appropriately within recommended treatment durations.