Ponstel: Effective Relief for Menstrual Pain and Inflammation
| Product dosage: 250mg | |||
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Ponstel (mefenamic acid) is a prescription nonsteroidal anti-inflammatory drug (NSAID) specifically formulated to provide targeted relief from moderate menstrual pain and inflammation. As a member of the fenamate class of NSAIDs, it works by inhibiting prostaglandin synthesis, addressing the root cause of pain and discomfort associated with menstrual cycles. Its rapid onset of action and focused efficacy make it a trusted choice among healthcare providers for managing primary dysmenorrhea. This product card provides a comprehensive, expert-level overview of Ponstel, including its mechanism, appropriate use, and important safety considerations.
Features
- Active ingredient: mefenamic acid 250 mg per capsule
- Pharmaceutical class: nonsteroidal anti-inflammatory drug (NSAID), fenamate group
- Administration: oral capsule
- Available in bottles of 100 and 500 capsules
- Prescription-only medication
- Onset of action: typically within 1–2 hours post-administration
- Half-life: approximately 2–4 hours
- Excretion: primarily renal
Benefits
- Provides rapid and effective relief from moderate menstrual pain (dysmenorrhea)
- Reduces uterine inflammation and prostaglandin-induced cramping
- Alleviates associated symptoms such as headache and lower back pain
- Enables improved daily functioning and quality of life during menstruation
- Short-term use minimizes risk of systemic side effects compared to chronic NSAID therapy
- Trusted and specifically indicated for menstrual discomfort
Common use
Ponstel is primarily indicated for the relief of moderate pain in patients with primary dysmenorrhea. It is also used for the short-term management of mild to moderate pain, including musculoskeletal pain, dental pain, and postoperative discomfort. Its anti-inflammatory and analgesic properties make it suitable for conditions where prostaglandin mediation is a key factor in symptom generation. Use is generally limited to a few days during the menstrual period or for acute pain episodes, in accordance with prescribing guidelines.
Dosage and direction
For the treatment of primary dysmenorrhea, the recommended dosage is 500 mg as an initial dose, followed by 250 mg every 6 hours as needed. Treatment should not exceed 3–4 days. Ponstel should be taken with food or milk to minimize gastrointestinal upset. Do not crush or chew capsules; swallow whole with a full glass of water. Dosage adjustments may be necessary for elderly patients or those with renal impairment. Always follow the specific instructions provided by your healthcare provider.
Precautions
Patients should be advised to use the lowest effective dose for the shortest duration possible. Ponstel may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. There is also an increased risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines. Use with caution in patients with a history of cardiovascular disease, hypertension, or gastrointestinal disorders. Periodic monitoring of renal function, blood pressure, and hemoglobin is recommended during therapy.
Contraindications
Ponstel is contraindicated in patients with known hypersensitivity to mefenamic acid, aspirin, or other NSAIDs. It should not be used in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Additional contraindications include the peri-operative setting of coronary artery bypass graft (CABG) surgery, and in patients with active peptic ulcer disease or a history of recurrent ulceration/bleeding. Severe heart failure, hepatic impairment, and renal impairment are also contraindications.
Possible side effects
Common side effects include gastrointestinal symptoms such as dyspepsia, nausea, vomiting, diarrhea, and abdominal pain. Other frequently reported reactions include dizziness, headache, and nervousness. Serious side effects may include gastrointestinal bleeding, hepatotoxicity, renal impairment, hypertension, heart failure, and severe skin reactions. Patients should seek immediate medical attention if they experience symptoms of chest pain, shortness of breath, weakness on one side of the body, slurred speech, black or bloody stools, or skin rash.
Drug interaction
Ponstel may interact with anticoagulants (e.g., warfarin), antiplatelet agents, and selective serotonin reuptake inhibitors (SSRIs), increasing the risk of bleeding. Concurrent use with other NSAIDs or corticosteroids may elevate the risk of gastrointestinal adverse events. It may reduce the effect of antihypertensive agents and diuretics. Ponstel can increase lithium and methotrexate levels, necessitating close monitoring. Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next scheduled dose. Do not double the dose to make up for a missed one. Since Ponstel is typically used on an as-needed basis for menstrual pain, strict adherence to a dosing schedule is less critical than with chronic medications. Consult your prescriber if unsure.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, coma, or acute renal failure. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Management is supportive and symptomatic; there is no specific antidote. Hemodialysis is not effective due to high protein binding.
Storage
Store at room temperature (20–25°C or 68–77°F), in a tightly closed container, away from light, moisture, and heat. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Dispose of unused medication properly according to local regulations; do not flush down the toilet or pour into drains.
Disclaimer
This information is intended for educational purposes only and does not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new medication or making changes to your treatment plan. Individual responses to medication may vary. Ponstel is a prescription drug and should only be used under the supervision of a qualified healthcare professional.
Reviews
Clinical studies and patient reports indicate that Ponstel is effective in reducing menstrual pain for many individuals. Users often note significant improvement in cramping and associated symptoms within a few hours of the first dose. Some report mild gastrointestinal side effects, which are generally manageable when taken with food. Healthcare providers appreciate its targeted action and short-term use profile, though emphasis is placed on adhering to prescribed duration and dosage to minimize risks. Long-term satisfaction is high among appropriate candidate populations when used as directed.