Motrin is a trusted, nonsteroidal anti-inflammatory drug (NSAID) containing ibuprofen as its active ingredient. It is widely utilized in clinical and over-the-counter settings for its potent analgesic, anti-inflammatory, and antipyretic properties. Healthcare professionals frequently recommend Motrin for the management of mild to moderate pain, reduction of fever, and alleviation of inflammation associated with various conditions. Its mechanism of action involves inhibition of cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis. This product is available in multiple formulations, including tablets, caplets, and liquid suspensions, to accommodate diverse patient needs and preferences.

Features

• Active ingredient: Ibuprofen (NSAID)
• Available in 200 mg, 400 mg, 600 mg, and 800 mg tablet strengths
• Also supplied as oral suspension (100 mg/5 mL) for pediatric and adult use
• Coated tablets for easier swallowing and reduced gastric irritation
• Rapid absorption with onset of action typically within 30 minutes
• Duration of effect: 4 to 6 hours per dose
• Non-prescription (OTC) and prescription formulations available
• Gluten-free and dye-free options in select products

Benefits

• Provides effective relief from mild to moderate pain, including headache, dental pain, menstrual cramps, and musculoskeletal discomfort
• Reduces inflammation and associated symptoms in conditions such as arthritis, tendonitis, and bursitis
• Lowers fever quickly and safely in both adults and children
• Allows for improved mobility and daily functioning by alleviating pain and stiffness
• Available without a prescription for convenient access to symptom management
• Multiple dosage forms enable individualized and age-appropriate dosing

Common use

Motrin is commonly used for the temporary relief of minor aches and pains due to the common cold, headache, toothache, backache, menstrual cramps, or minor injury. It is also indicated for the reduction of fever. For inflammatory conditions such as osteoarthritis or rheumatoid arthritis, it helps decrease pain, swelling, and joint stiffness. Athletes and active individuals may use it for acute musculoskeletal pain or post-exercise soreness. Always use the smallest effective dose for the shortest duration necessary.

Dosage and direction

Adults: For pain/fever: 200–400 mg orally every 4–6 hours as needed. Maximum OTC dose: 1200 mg per day. Under medical supervision, prescription doses up to 3200 mg/day may be used in divided doses.
Children: Dosing based on weight (5–10 mg/kg per dose) every 6–8 hours. Maximum daily dose: 40 mg/kg. Use provided measuring device for liquid formulations.
Take with food or milk to minimize stomach upset. Do not crush, chew, or break tablets unless directed. Do not use for more than 10 days for pain or 3 days for fever unless directed by a physician.

Precautions

• Use with caution in patients with a history of gastrointestinal ulceration or bleeding
• Monitor renal function in those with pre-existing kidney impairment, dehydration, or heart failure
• Avoid use in patients with cardiovascular disease or risk factors unless advised by a healthcare provider
• May cause dizziness or drowsiness; use caution when driving or operating machinery
• Not recommended during the third trimester of pregnancy
• Long-term use should be supervised by a clinician due to risks of GI, renal, and cardiovascular events

Contraindications

• Hypersensitivity to ibuprofen, aspirin, or other NSAIDs
• History of asthma, urticaria, or allergic-type reactions after taking NSAIDs
• Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
• Active peptic ulcer disease or gastrointestinal bleeding
• Severe renal impairment or end-stage renal disease
• Third trimester of pregnancy

Possible side effect

Common side effects may include nausea, dyspepsia, heartburn, diarrhea, constipation, abdominal cramps, dizziness, headache, nervousness, or rash. Less frequently, gastrointestinal ulceration, bleeding, or perforation may occur. Renal effects such as reduced function, acute kidney injury, or interstitial nephritis are possible, especially with prolonged use. Elevated liver enzymes, fluid retention, edema, hypertension, and increased cardiovascular thrombotic events have been reported. Seek medical attention if symptoms such as black/tarry stools, vomiting blood, chest pain, shortness of breath, weakness on one side, or slurred speech occur.

Drug interaction

• Anticoagulants (e.g., warfarin): Increased risk of bleeding
• Aspirin: May diminish cardioprotective effects and increase GI risk
• ACE inhibitors/ARBs: Reduced antihypertensive effect; possible worsening renal function
• Diuretics: Reduced efficacy; potential for renal impairment
• Corticosteroids, SSRIs: Increased risk of GI bleeding
• Lithium, methotrexate: Increased plasma levels and potential toxicity
• Other NSAIDs: Avoid concomitant use due to additive adverse effects

Missed dose

If using on a scheduled basis and a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. For as-needed use, resume normal dosing with the next episode of pain or fever.

Overdose

Symptoms may include nausea, vomiting, epigastric pain, drowsiness, blurred vision, nystagmus, metabolic acidosis, coma, acute renal failure, apnea, or seizures. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Do not induce vomiting unless directed by medical personnel. Treatment is supportive and may include gastric lavage, activated charcoal, and correction of electrolyte imbalances.

Storage

Store at room temperature (20–25°C or 68–77°F). Keep tightly closed in original container. Protect from light and moisture. Do not freeze liquid formulation. Keep out of reach of children and pets. Do not use after the expiration date printed on packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or qualified healthcare provider with any questions regarding a medical condition or before starting any new treatment. Do not disregard professional medical advice or delay seeking it because of something you have read here.

Reviews

Motrin is consistently rated highly by consumers and healthcare professionals for its efficacy in pain and fever reduction. Many users report rapid relief from headaches, muscle pain, and menstrual discomfort. Pediatric formulations are frequently praised for their palatability and ease of administration. Some note gastrointestinal side effects with prolonged use, underscoring the importance of short-term use and taking with food. Clinical studies support its role as a first-line option for mild to moderate pain and inflammation management.