Lasix: Effective Diuretic for Rapid Fluid Reduction
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $3.87 | $38.70 (0%) | 🛒 Add to cart |
| 20 | $2.15 | $77.40 $43.00 (44%) | 🛒 Add to cart |
| 30 | $1.58 | $116.10 $47.30 (59%) | 🛒 Add to cart |
| 60 | $0.86 | $232.20 $51.60 (78%) | 🛒 Add to cart |
| 90 | $0.67 | $348.30 $60.20 (83%) | 🛒 Add to cart |
| 120 | $0.57 | $464.40 $68.80 (85%) | 🛒 Add to cart |
| 180 | $0.43 | $696.60 $77.40 (89%) | 🛒 Add to cart |
| 270 | $0.38 | $1044.90 $103.20 (90%) | 🛒 Add to cart |
| 360 | $0.33
Best per pill | $1393.20 $120.40 (91%) | 🛒 Add to cart |
Similar products
Lasix (furosemide) is a potent loop diuretic widely utilized in clinical practice for the management of edema associated with congestive heart failure, liver cirrhosis, and renal disease. Its primary mechanism involves inhibiting sodium and chloride reabsorption in the ascending loop of Henle, promoting significant fluid excretion. This medication is valued for its rapid onset and predictable pharmacokinetics, making it a cornerstone therapy in both acute and chronic settings where volume overload necessitates prompt intervention.
Features
- Contains furosemide as the active ingredient
- Available in oral tablets (20 mg, 40 mg, 80 mg) and injectable formulations
- Rapid onset of action: diuresis begins within 60 minutes orally, 5 minutes IV
- High bioavailability (~60-70%) with peak effect at 1-2 hours
- Excreted largely unchanged in urine
- Compatible with most standard pharmaceutical excipients
Benefits
- Rapid reduction of edema and pulmonary congestion
- Decreased cardiac preload in heart failure, alleviating symptoms like dyspnea
- Effective management of hypertension through volume reduction
- Useful in treating hypercalcemia and certain cases of acute renal failure
- Facilitates sodium and water excretion even in impaired renal function
- Can be titrated easily based on clinical response and renal function
Common use
Lasix is primarily indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including nephrotic syndrome. It is also used in the management of hypertension, either alone or in combination with other antihypertensive agents. In hospital settings, intravenous Lasix is frequently administered for acute pulmonary edema and for forced diuresis in cases of drug overdose. Off-label uses include treatment of hypercalcemia and some forms of refractory edema.
Dosage and direction
Dosage must be individualized based on patient response and clinical condition. For edema in adults: initial oral dose is 20-80 mg given as a single dose, preferably in the morning. Depending on response, another dose may be given 6-8 hours later. Maintenance doses may be given once or twice daily. For hypertension: initial dose is 40 mg twice daily, adjusted according to response. IV administration: 20-40 mg injected slowly over 1-2 minutes, may be repeated in 2 hours if needed. For pediatric patients: 2 mg/kg orally, adjusted based on response. Always take with food or milk to minimize gastric upset.
Precautions
Monitor blood pressure, renal function, and electrolytes regularly. Risk of hypokalemia necessitates potassium supplementation or potassium-sparing diuretics in some patients. Use cautiously in patients with hepatic cirrhosis and ascites due to risk of hepatic encephalopathy. Ototoxicity may occur, especially with rapid IV administration or concurrent use of other ototoxic drugs. Photosensitivity reactions may occur; advise sun protection. Elderly patients may be more sensitive to effects and require lower doses.
Contraindications
Anuria; hypersensitivity to furosemide or sulfonamide-derived drugs; hepatic coma; severe electrolyte depletion; patients with known sulfa allergy. Not recommended during breastfeeding due to secretion in breast milk. Should not be used in patients with untreated digitalis toxicity due to risk of fatal arrhythmias from hypokalemia.
Possible side effect
Common: dehydration, hypokalemia, hyponatremia, hypochloremia, hypocalcemia, hypomagnesemia, hyperglycemia, hyperuricemia, orthostatic hypotension. Gastrointestinal: nausea, vomiting, diarrhea, constipation. Less common: pancreatitis, blurred vision, tinnitus, hearing loss, rash, photosensitivity, hematologic changes (leukopenia, thrombocytopenia). Rare: Stevens-Johnson syndrome, toxic epidermal necrolysis, interstitial nephritis.
Drug interaction
Enhanced hypotensive effect with other antihypertensives. Increased risk of ototoxicity with aminoglycosides. NSAIDs may reduce diuretic effect. Enhanced risk of hypokalemia with corticosteroids, amphotericin B. May potentiate effects of skeletal muscle relaxants. Lithium excretion decreased, risk of toxicity. May increase risk of digoxin toxicity due to potassium depletion. Probenecid may reduce diuretic effect.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one. If taking twice daily and missed the morning dose, take it with the evening dose only if at least 6 hours apart. Consistent dosing is important for therapeutic effect, but occasional missed doses are unlikely to cause significant clinical deterioration.
Overdose
Symptoms include profound water loss, electrolyte depletion (especially potassium, sodium, chloride), dehydration, reduced blood volume, circulatory collapse with possibility of vascular thrombosis and embolism. Treatment involves electrolyte replacement and volume resuscitation. There is no specific antidote; management is supportive with careful monitoring of fluid and electrolyte status. Hemodialysis does not significantly enhance elimination.
Storage
Store at room temperature (15-30°C/59-86°F) in a dry place protected from light. Keep in original container with lid tightly closed. Do not freeze. Keep out of reach of children and pets. Do not use if tablets show signs of discoloration or deterioration. Properly discard any unused medication after expiration date.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting or changing any medication regimen. Dosage and treatment decisions should be made based on individual patient assessment by a licensed physician. The prescriber should be familiar with complete prescribing information and current clinical guidelines.
Reviews
Clinical studies consistently demonstrate Lasix’s efficacy in edema reduction, with 70-80% of heart failure patients showing significant improvement in dyspnea and edema within 24-48 hours. Meta-analyses confirm its superiority over thiazide diuretics in severe edema cases. Many nephrologists consider it first-line for volume overload in renal impairment. Some reports note electrolyte disturbances as the most common management challenge. Overall, it remains a gold standard diuretic despite introduction of newer agents.