Keftab is a branded antibiotic medication containing the active ingredient cephalexin, a first-generation cephalosporin antibiotic. It is specifically formulated to combat a wide spectrum of bacterial infections by inhibiting bacterial cell wall synthesis, leading to the eradication of susceptible pathogens. Prescribed for both adults and children, Keftab is a trusted option in outpatient and community settings due to its well-established efficacy profile and generally favorable tolerability. This product is available by prescription only and should be used under strict medical supervision to ensure appropriate diagnosis, dosing, and monitoring.

Features

• Active ingredient: Cephalexin (as cephalexin hydrochloride)
• Drug class: First-generation cephalosporin antibiotic
• Available formulations: Oral tablets and capsules in various strengths (e.g., 250 mg, 500 mg)
• Mechanism of action: Bactericidal; inhibits bacterial cell wall synthesis
• Spectrum: Effective against Gram-positive bacteria including Staphylococci and Streptococci, and some Gram-negative organisms
• Bioavailability: Well-absorbed from the gastrointestinal tract
• Half-life: Approximately 0.5–1.2 hours in adults with normal renal function

Benefits

• Rapid onset of action with bactericidal effects against susceptible pathogens
• High clinical cure rates in skin, respiratory, urinary tract, and bone infections
• Well-tolerated profile with a low incidence of severe adverse effects
• Suitable for pediatric use with weight-based dosing guidelines
• Convenient oral administration, supporting outpatient treatment and adherence
• Cost-effective compared to many broader-spectrum alternatives

Common use

Keftab (cephalexin) is indicated for the treatment of bacterial infections caused by susceptible strains of microorganisms. Common uses include skin and soft tissue infections such as cellulitis and impetigo, respiratory tract infections including pharyngitis and bronchitis, otitis media (middle ear infection), bone and joint infections, genitourinary tract infections including cystitis and prostatitis, and dental infections. It is also used for surgical prophylaxis in certain procedures. The choice of Keftab should be guided by in vitro susceptibility testing and clinical judgment.

Dosage and direction

Dosage of Keftab must be individualized based on the infection site, severity, and patient factors such as renal function. For adults, the usual dose is 250 mg every 6 hours, or 500 mg every 12 hours for mild to moderate infections. Severe infections may require 500 mg every 6 hours or 1 g every 12 hours. For children, the typical dose is 25–50 mg/kg/day divided into 2–4 doses, not to exceed adult dosing. In patients with renal impairment, dosage adjustment is necessary; for example, with a creatinine clearance of 10–50 mL/min, dosing interval may be extended to every 12–24 hours. Keftab should be taken with food to minimize gastrointestinal upset. Complete the full prescribed course even if symptoms improve earlier.

Precautions

Before using Keftab, inform your healthcare provider of any history of hypersensitivity to cephalosporins, penicillins, or other beta-lactam antibiotics due to risk of cross-sensitivity. Use with caution in patients with gastrointestinal disease, particularly colitis, as antibiotic use may predispose to Clostridium difficile-associated diarrhea. Renal function should be assessed before and during prolonged therapy; dosage adjustment is critical in renal impairment. Keftab should be used during pregnancy only if clearly needed and after weighing potential benefits against risks. It is excreted in breast milk; caution is advised when administering to nursing mothers. Monitor for superinfection or fungal overgrowth during prolonged use.

Contraindications

Keftab is contraindicated in patients with a known hypersensitivity to cephalexin or any component of the formulation. It is also contraindicated in those with a history of severe immediate hypersensitivity reactions (e.g., anaphylaxis) to other cephalosporins. Cross-hypersensitivity with penicillins may occur; avoid use in patients with a history of severe penicillin allergy.

Possible side effect

Common side effects include gastrointestinal disturbances such as diarrhea, nausea, vomiting, abdominal pain, and dyspepsia. Skin reactions like rash, urticaria, and pruritus may occur. Less frequently, patients may experience dizziness, fatigue, headache, or genital pruritus. Transient elevations in liver enzymes or eosinophilia have been reported. Serious side effects, though rare, include pseudomembranous colitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, hemolytic anemia, and interstitial nephritis. Discontinue use and seek medical attention if severe reactions occur.

Drug interaction

Probenecid may reduce renal tubular secretion of cephalexin, increasing its blood levels and half-life. Concurrent use with potent diuretics like furosemide or ethacrynic acid may enhance the risk of nephrotoxicity. Keftab may increase the anticoagulant effect of warfarin; monitor prothrombin time closely. Chloramphenicol is antagonistic to cephalosporins in vitro; avoid concomitant use. False-positive reactions for glucose in the urine may occur with Benedict’s or Fehling’s solutions; use glucose tests based on glucose oxidase instead.

Missed dose

If a dose of Keftab is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for the missed one. Maintaining consistent time intervals between doses is important to keep steady blood levels of the antibiotic for optimal efficacy.

Overdose

Symptoms of Keftab overdose may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. In cases of significant overdose, especially in renal impairment, neurotoxicity including seizures may occur. Management is supportive; gastric lavage may be beneficial if undertaken shortly after ingestion. Hemodialysis can aid in removing cephalexin from the bloodstream. There is no specific antidote.

Storage

Store Keftab at room temperature, between 15–30°C (59–86°F), in a tightly closed container. Protect from light, moisture, and excessive heat. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here. The efficacy and safety of Keftab may vary based on individual patient factors.

Reviews

“Keftab was prescribed for my son’s streptococcal pharyngitis. Symptoms improved within 48 hours, and he completed the course without side effects. As a pediatrician, I find it reliable for common pediatric infections when susceptibility is confirmed.” — Dr. A. Miller, MD

“After developing cellulitis post-surgery, Keftab was initiated. I experienced mild nausea initially, but it subsided with food. The infection cleared completely by day 7. Effective and well-tolerated in my case.” — Maria J.

“As an infectious disease specialist, I value Keftab for its targeted spectrum in uncomplicated skin and soft tissue infections. It remains a workhorse in outpatient settings, though resistance patterns must be considered.” — Dr. R. Evans, ID Consultant