Floxin: Potent Antibiotic for Severe Bacterial Infections
| Product dosage: 200mg | |||
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Floxin (ofloxacin) is a broad-spectrum fluoroquinolone antibiotic indicated for the treatment of serious bacterial infections where first-line therapies have failed or are contraindicated. As a second-generation quinolone, it demonstrates excellent tissue penetration and bactericidal activity against both Gram-positive and Gram-negative pathogens, including many multidrug-resistant strains. Medical professionals prescribe Floxin for complicated infections when narrower-spectrum antibiotics prove ineffective, making it a critical tool in managing difficult clinical scenarios.
Features
- Active ingredient: Ofloxacin 200mg/400mg tablets
- Broad-spectrum activity against aerobic Gram-positive and Gram-negative bacteria
- Excellent oral bioavailability (>95%) with rapid absorption
- Superior tissue penetration including prostate, lung, and skin structure concentrations
- Bactericidal mechanism through inhibition of bacterial DNA gyrase and topoisomerase IV
- FDA-approved for multiple infection sites including urinary tract, respiratory, and skin structures
Benefits
- Effective against multidrug-resistant pathogens including Pseudomonas aeruginosa
- Rapid clinical response due to high tissue concentration and bactericidal action
- Convenient twice-daily dosing regimen improves patient compliance
- Comprehensive coverage reduces need for combination antibiotic therapy
- Well-established safety profile with extensive clinical documentation
- Cost-effective alternative to newer broad-spectrum antibiotics
Common use
Floxin is commonly prescribed for complicated urinary tract infections, including pyelonephritis, particularly when caused by multidrug-resistant organisms. It demonstrates efficacy in lower respiratory tract infections such as community-acquired pneumonia and acute exacerbations of chronic bronchitis. Dermatologists frequently utilize Floxin for complicated skin and skin structure infections, including surgical wound infections and abscesses. The medication is also indicated for sexually transmitted diseases including multidrug-resistant gonorrhea and chlamydial infections when tetracyclines are contraindicated.
Dosage and direction
The standard adult dosage for most infections is 400mg orally every 12 hours. For urinary tract infections, 200mg every 12 hours may be sufficient. Treatment duration typically ranges from 7 to 14 days depending on infection severity and clinical response. Patients should take tablets with a full glass of water, either one hour before or two hours after meals to optimize absorption. Dosage adjustment is required in renal impairment: for creatinine clearance 20-50 mL/min, administer normal dose every 24 hours; for clearance <20 mL/min, administer half the normal dose every 24 hours.
Precautions
Patients should maintain adequate hydration to prevent crystal formation in urine. Avoid excessive sunlight exposure and use protective measures due to photosensitivity risk. Monitor for tendon pain or inflammation, particularly in elderly patients or those concurrently using corticosteroids. Use with caution in patients with known or suspected central nervous system disorders due to potential neuroexcitatory effects. Regular renal function monitoring is advised during extended therapy. Diabetic patients require glucose monitoring as quinolones may affect blood sugar levels.
Contraindications
Floxin is contraindicated in patients with known hypersensitivity to ofloxacin or other quinolone antibiotics. It must not be administered to patients with history of tendon disorders related to quinolone use. The medication is contraindicated in pediatric patients, adolescents, and pregnant women due to potential effects on cartilage development. Avoid use in patients with known QT prolongation or those taking medications that prolong QT interval. Concurrent administration with tizanidine is absolutely contraindicated.
Possible side effect
Common adverse effects (≥1%) include nausea (3-5%), headache (2-4%), dizziness (2-3%), and insomnia (1-2%). Gastrointestinal disturbances such as diarrhea and abdominal pain occur in approximately 2-3% of patients. Photosensitivity reactions develop in 1-2% of users. Serious but rare side effects (<0.1%) include tendon rupture, peripheral neuropathy, and psychiatric reactions including anxiety and depression. Hepatotoxicity manifested by elevated transaminases occurs in approximately 1% of patients. Clostridium difficile-associated diarrhea may develop during or after treatment.
Drug interaction
Concurrent administration with antacids containing magnesium, aluminum, or calcium reduces ofloxacin absorption by up to 90%. NSAIDs may increase CNS excitation risk. Warfarin requires close INR monitoring due to potentiation of anticoagulant effect. Probenecid decreases renal clearance of ofloxacin, increasing systemic exposure. QT-prolonging agents including antiarrhythmics and antipsychotics may produce additive cardiac effects. Theophylline levels may increase, requiring dosage adjustment and therapeutic monitoring.
Missed dose
If a dose is missed, administer it as soon as remembered unless it is nearly time for the next scheduled dose. Do not double the dose to make up for missed administration. Maintain the regular dosing schedule without additional tablets. If multiple doses are missed, contact the prescribing physician for guidance on resumption of therapy. Consistent dosing is crucial for maintaining therapeutic drug concentrations and preventing antibiotic resistance development.
Overdose
Symptoms of overdose may include severe dizziness, nausea, vomiting, and CNS excitation including seizures. Management involves gastric lavage if presentation occurs within two hours of ingestion. Maintain adequate hydration and electrolyte balance. Hemodialysis removes approximately 20-30% of circulating ofloxacin and may be considered in severe cases. Symptomatic treatment for specific manifestations should be instituted. There is no specific antidote for quinolone overdose. Monitor ECG for QT prolongation and provide cardiac monitoring for 24-48 hours post-ingestion.
Storage
Store at controlled room temperature (20-25°C or 68-77°F) in the original container. Protect from light and excessive moisture. Keep tightly closed and out of reach of children. Do not store in bathroom cabinets due to humidity fluctuations. Discard any unused medication after completion of therapy or upon expiration date. Do not transfer tablets to other containers as this may affect stability. Avoid freezing the medication.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any medication. The prescribing physician should make final determinations regarding appropriate therapy based on individual patient factors. Dosage and administration may vary based on specific clinical circumstances. Report any adverse reactions to healthcare provider immediately.
Reviews
Clinical studies demonstrate Floxin achieves clinical cure rates of 85-92% in complicated urinary tract infections and 82-88% in respiratory infections. Meta-analyses confirm superior efficacy compared to older quinolones with comparable safety profile. Many infectious disease specialists appreciate its reliability in managing difficult Pseudomonas infections. Some clinicians note the need for careful patient selection due to potential adverse effects. Overall, Floxin remains a valuable therapeutic option when prescribed appropriately for indicated infections.