Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) prescribed for the management of pain and inflammation associated with osteoarthritis and rheumatoid arthritis. It functions by inhibiting the body’s production of substances that cause inflammation, pain, and fever. This medication offers a focused approach to improving joint function and reducing discomfort, enabling greater daily mobility. It is available in both immediate-release and extended-release tablet formulations to suit varying therapeutic needs.

Features

• Active pharmaceutical ingredient: Etodolac
• Available in tablet form (immediate-release and extended-release)
• Prescription-only medication
• Multiple strengths: 400 mg, 500 mg, and 600 mg
• COX-2 selective inhibitor (relatively more selective)
• White to off-white, round, film-coated tablets

Benefits

• Effectively reduces inflammation at the site of pain
• Provides relief from mild to moderate arthritic pain
• Helps improve joint mobility and physical function
• May allow for reduced dependence on additional pain medications
• Long-acting formulations support all-day or all-night symptom control
• Contributes to enhanced quality of life and daily activity participation

Common use

Etodolac is commonly used for the symptomatic treatment of osteoarthritis and rheumatoid arthritis. It is also occasionally prescribed for the management of acute pain, such as that following dental or surgical procedures, though this is an off-label use. Its primary role is to decrease inflammation, stiffness, and joint pain, helping patients maintain a more active and comfortable lifestyle.

Dosage and direction

The dosage of etodolac must be individualized under medical supervision. For osteoarthritis and rheumatoid arthritis, the usual recommended starting dose for adults is 300 mg two or three times daily, or 400 mg twice daily. For the extended-release tablets, the typical dose is 400 mg to 1000 mg taken once daily. It should be taken with a full glass of water and with food or milk to minimize stomach upset. Do not crush, chew, or break extended-release tablets. Always use the lowest effective dose for the shortest duration possible.

Precautions

Before using etodolac, inform your healthcare provider if you have a history of asthma, bleeding or clotting disorders, heart disease, high blood pressure, liver or kidney disease, or stomach/intestinal disorders such as ulcers. Avoid alcohol and tobacco during treatment, as these may increase the risk of stomach bleeding. Regular monitoring of kidney function, blood counts, and blood pressure may be advised during long-term therapy. Etodolac may cause dizziness or drowsiness; use caution when driving or operating machinery.

Contraindications

Etodolac is contraindicated in patients with known hypersensitivity to etodolac, aspirin, or other NSAIDs. It should not be used in individuals who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Do not use during the peri-operative period of coronary artery bypass graft (CABG) surgery. Contraindicated in patients with a history of gastrointestinal bleeding or perforation related to previous NSAID therapy. Not recommended in severe heart failure or advanced kidney disease.

Possible side effect

Common side effects may include nausea, diarrhea, indigestion, abdominal pain, dizziness, and headache. Serious side effects can include signs of gastrointestinal bleeding (black/tarry stools, vomiting blood), symptoms of heart problems (chest pain, shortness of breath, weakness on one side of the body), liver problems (nausea, fatigue, jaundice), kidney issues (change in urine amount), or severe skin reactions. Seek immediate medical attention if any severe symptoms occur.

Drug interaction

Etodolac may interact with anticoagulants (e.g., warfarin), antiplatelet drugs, other NSAIDs, corticosteroids, SSRIs, ACE inhibitors, angiotensin II receptor blockers, diuretics, lithium, and methotrexate. It may reduce the effectiveness of aspirin when taken concurrently. Always inform your doctor of all prescription, over-the-counter, and herbal products you are using.

Missed dose

If you miss a dose of etodolac, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Overdose

Symptoms of overdose may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, vomiting blood, breathing difficulties, or coma. In case of suspected overdose, seek emergency medical attention or contact a poison control center immediately.

Storage

Store etodolac at room temperature (20°C to 25°C or 68°F to 77°F), away from moisture, light, and heat. Keep in the original container, tightly closed, and out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

“After six months of use for osteoarthritis in my knee, I’ve noticed a significant reduction in swelling and pain. I can walk longer distances without discomfort.” — Maria, 62
“My rheumatologist prescribed etodolac for my rheumatoid arthritis flare-ups. It works well for stiffness, though I take it with food to avoid stomach issues.” — James, 45
“Effective for pain, but I experienced mild dizziness during the first week. It subsided after that. Regular blood tests are important.” — Linda, 58
“I’ve been using the extended-release version for a year. It offers all-day relief and has greatly improved my mobility.” — Robert, 70
“Helped with inflammation post-surgery, but I was advised to use it short-term due to my history of acid reflux.” — Sarah, 41