Estriol: Targeted Hormone Therapy for Menopausal Symptom Relief
| Product dosage: 1 g | |||
|---|---|---|---|
| Package (num) | Per tube | Price | Buy |
| 1 | $29.24 | $29.24 (0%) | 🛒 Add to cart |
| 2 | $27.52 | $58.48 $55.04 (6%) | 🛒 Add to cart |
| 3 | $26.09 | $87.72 $78.26 (11%) | 🛒 Add to cart |
| 4 | $25.16 | $116.96 $100.62 (14%) | 🛒 Add to cart |
| 5 | $23.56
Best per tube | $146.20 $117.82 (19%) | 🛒 Add to cart |
Synonyms | |||
Estriol is a bioidentical estrogen hormone primarily indicated for the management of urogenital atrophy and associated symptoms in postmenopausal individuals. As the weakest of the three primary endogenous estrogens, it offers a favorable safety profile with selective tissue activity, particularly in the vagina and lower urinary tract. Its use is supported by clinical evidence for localized symptom relief with minimal systemic absorption when applied topically, making it a valuable option in hormone replacement regimens.
Features
- Contains estriol, a naturally occurring estrogen
- Available in topical formulations including cream, gel, and vaginal suppositories
- Low systemic absorption with localized tissue effects
- Bioidentical structure identical to endogenous human estriol
- Multiple concentration options for individualized dosing
- Typically prescribed as part of comprehensive menopausal management
Benefits
- Effectively relieves vaginal dryness, itching, and burning associated with menopause
- Reduces frequency of urinary tract infections and urinary urgency
- Improves vaginal epithelial health and elasticity
- Minimizes systemic estrogenic effects compared to stronger estrogens
- Supports comfortable sexual intercourse by restoring vaginal moisture
- May provide relief from some perimenopausal symptoms with proper dosing
Common use
Estriol is primarily prescribed for the treatment of urogenital atrophy in postmenopausal individuals. It is particularly effective for symptoms including vaginal dryness, dyspareunia (painful intercourse), pruritus, and urinary symptoms related to estrogen deficiency. Clinicians may also consider estriol as part of compounded hormone regimens for individuals who cannot tolerate standard estrogen therapy or require more customized dosing. Off-label uses may include some dermatological applications, though evidence for these uses is more limited.
Dosage and direction
Dosage varies by formulation and individual needs. For vaginal cream (0.01%): Typically 2-4 grams applied intravaginally daily for 2-4 weeks, then reduced to half the dose three times per week. Vaginal suppositories: Usually one suppository (0.5 mg) daily for 2-3 weeks, then maintenance dosing 2-3 times weekly. Topical gel formulations are dosed according to specific product guidelines. Always apply at the same time each day for consistent effects. Wash hands thoroughly after application. Dosage adjustments should be made gradually under medical supervision based on symptom response and tolerance.
Precautions
Regular monitoring of endometrial status is recommended, especially in women with an intact uterus. Periodic reevaluation of the continued need for therapy is advised. Use with caution in patients with conditions that might be influenced by fluid retention (asthma, epilepsy, migraine, cardiac or renal dysfunction). Monitor blood pressure in hypertensive patients. Breast examinations and mammograms should follow recommended screening guidelines. Discontinue use immediately if jaundice, abnormal liver function, or thrombotic events occur. Not recommended for use beyond the treatment period necessary to control symptoms.
Contraindications
Known or suspected pregnancy; nursing mothers; undiagnosed abnormal genital bleeding; known or suspected estrogen-dependent neoplasia; active or history of deep vein thrombosis or pulmonary embolism; active or recent arterial thromboembolic disease; liver dysfunction or disease; known hypersensitivity to estriol or any product components.
Possible side effects
Common: Vaginal irritation, itching, or discharge; breast tenderness; headache; nausea. Less common: Fluid retention; weight changes; mood changes; abdominal cramps; bloating; hair loss; changes in libido. Rare: Allergic reactions; worsening of endometriosis; hypertension; gallbladder disease; increased risk of blood clots. Most side effects are dose-dependent and often diminish with continued use or dosage adjustment.
Drug interaction
May reduce effectiveness of tamoxifen. Barbiturates, carbamazepine, rifampin, and St. John’s wort may decrease estrogen levels. Estriol may alter the metabolism of corticosteroids, cyclosporine, and theophylline. May increase thyroid-binding globulin levels, requiring adjustment of thyroid replacement dosage. Can potentially interact with blood thinners (warfarin) requiring closer monitoring. Always inform your healthcare provider of all medications, including over-the-counter products and supplements.
Missed dose
Apply the missed dose as soon as remembered, unless it is almost time for the next dose. Do not double the dose to make up for a missed application. Maintain the regular dosing schedule. If multiple doses are missed, contact your healthcare provider for guidance on resuming therapy. Consistency in application is important for optimal symptom control.
Overdose
Acute overdose with topical estriol is unlikely due to limited systemic absorption. However, symptoms may include nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. There is no specific antidote. Treatment should be symptomatic and supportive. In case of accidental ingestion, seek medical attention immediately. Medical supervision is recommended for evaluation and appropriate management.
Storage
Store at room temperature (15-30°C or 59-86°F). Keep tightly closed in the original container. Protect from light and moisture. Do not freeze. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly discard any unused medication after the treatment course is completed or if treatment is discontinued.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting or changing any treatment regimen. Individual results may vary. Proper diagnosis and supervision by a medical professional are essential for safe and effective use. This product should be used only as directed by a prescribing physician.
Reviews
“After struggling with painful intercourse for two years post-menopause, estriol cream has restored both comfort and intimacy. The improvement in vaginal health was noticeable within weeks, with minimal side effects.” - Patient, 58
“As a gynecologist, I find estriol particularly valuable for patients who cannot tolerate standard estrogen therapy. Its tissue-specific action and safety profile make it an excellent choice for managing urogenital symptoms without significant systemic exposure.” - Dr. Evans, MD
“After trying multiple lubricants and moisturizers, prescription estriol provided the actual physiological change my tissues needed. The difference in comfort and quality of life has been remarkable.” - Patient, 62
“The gradual dosing schedule and minimal systemic effects make estriol my first choice for older patients with isolated urogenital symptoms. Patient satisfaction and adherence are consistently high.” - Dr. Chen, OB-GYN