Duphaston (dydrogesterone) is a synthetic progestogen medication designed to mimic the effects of natural progesterone in the body. It is widely prescribed to address a range of hormone-related conditions, particularly those involving progesterone deficiency or imbalance. With its high selectivity for progesterone receptors and favorable safety profile, it offers a reliable option for managing menstrual disorders, supporting fertility, and maintaining early pregnancy. Its molecular structure contributes to predictable bioavailability and a reduced incidence of androgenic side effects compared to some older progestogens.

Features

• Contains dydrogesterone, a retroprogesterone with high oral bioavailability
• Selective action on progesterone receptors; minimal glucocorticoid, mineralocorticoid, or estrogenic activity
• Does not inhibit ovulation, making it suitable for fertility support
• Available in 10 mg tablet form for precise dosing
• Well-established clinical history with extensive research and global use

Benefits

• Effectively regulates irregular menstrual cycles and reduces heavy bleeding
• Supports endometrial preparation and maintenance in assisted reproductive technology (ART) cycles
• Reduces the risk of endometrial hyperplasia in estrogen replacement therapy
• Helps prevent miscarriage in women with proven progesterone deficiency
• Minimizes androgenic side effects such as acne or hirsutism
• Provides predictable, dose-dependent progestogenic activity without significant impact on metabolic parameters

Common use

Duphaston is commonly prescribed for the treatment of endometriosis, dysfunctional uterine bleeding, secondary amenorrhea, and premenstrual syndrome. It is also used in luteal phase support during infertility management, as part of hormone replacement therapy (combined with estrogen), and for the prevention of habitual or threatened abortion due to corpus luteum insufficiency.

Dosage and direction

Dosage varies by indication:

• Endometriosis: 10 mg two or three times daily from day 5 to day 25 of the cycle
• Infertility / Luteal support: 10 mg twice daily from day 14 to day 25 of the cycle, continued through early pregnancy if conception occurs
• Irregular menstruation: 10 mg twice daily from day 11 to day 25 of the cycle
• Hormone replacement therapy (with estrogen): 10 mg daily for the last 12–14 days of each cycle

Tablets should be taken orally with water, with or without food. Always follow the specific dosing regimen prescribed by a healthcare provider.

Precautions

Patients with a history of depression should use Duphaston with caution, as progestogens may exacerbate mood disorders. Regular monitoring of liver function is advised during long-term use. Use with caution in patients with existing renal impairment. Not intended for use as a contraceptive. Discontinue use if signs of thrombosis occur.

Contraindications

Duphaston is contraindicated in patients with known hypersensitivity to dydrogesterone or any excipients in the formulation. It should not be used in individuals with a history of progesterone-dependent neoplasms, undiagnosed vaginal bleeding, severe hepatic impairment, or acute porphyria.

Possible side effect

Common side effects may include:

• Nausea
• Headache
• Breast tenderness
• Mild abdominal discomfort
• Breakthrough bleeding or spotting

Rare but serious side effects include allergic reactions, jaundice, and signs of thromboembolism. Most side effects are mild and transient.

Drug interaction

Duphaston may interact with:

• CYP3A4 inducers (e.g., rifampicin, phenytoin, St. John’s wort), which may reduce its efficacy
• Anticoagulants (e.g., warfarin), potentially altering prothrombin time
• Other hormonal therapies, requiring careful dose adjustment

Inform your physician of all concomitant medications.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose. Consistent timing supports stable hormone levels.

Overdose

No specific antidote exists. Symptoms may include nausea, vomiting, and dizziness. Symptomatic and supportive treatment is recommended. Gastric lavage may be considered if ingestion was recent.

Storage

Store below 30°C (86°F) in a dry place, protected from light. Keep out of reach of children. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized dosage recommendations.

Reviews

Clinical studies and patient reports frequently highlight Duphaston’s efficacy in cycle regulation and pregnancy support. Many users note improved symptom control with fewer side effects compared to other progestins. However, individual responses may vary, and adherence to prescribed regimens is crucial for optimal outcomes.