Colospa (mebeverine hydrochloride) is an antispasmodic agent specifically formulated for the symptomatic treatment of Irritable Bowel Syndrome (IBS). It works by directly relaxing the smooth muscle in the intestinal wall, effectively reducing painful spasms without affecting normal gut motility. This targeted action helps restore digestive comfort, making it a cornerstone in the management of IBS-related abdominal pain and cramping. Its efficacy and favorable safety profile have made it a trusted choice for healthcare professionals worldwide.

Features

• Active Pharmaceutical Ingredient: Mebeverine Hydrochloride 135 mg.
• Pharmacological Class: Antispasmodic, musculotropic agent.
• Mechanism of Action: Exerts a direct relaxant effect on the gastrointestinal smooth muscle.
• Formulation: Film-coated tablets for oral administration.
• Prescription Status: Available by prescription in most regions.

Benefits

• Provides rapid and effective relief from abdominal cramps and pain associated with IBS.
• Acts directly on the gut smooth muscle, minimizing systemic side effects common with anticholinergic agents.
• Does not paralyze the bowel or interfere with normal peristalsis, reducing the risk of constipation or diarrhea.
• Helps improve overall quality of life by allowing patients to manage disruptive IBS symptoms.
• Offers a well-tolerated therapeutic option for long-term management of chronic IBS discomfort.

Common use

Colospa is primarily indicated for the symptomatic treatment of Irritable Bowel Syndrome (IBS). It is used to alleviate the hallmark symptoms of IBS, which include:

• Abdominal pain and cramping
• Bloating and distension
• Altered bowel habits (constipation, diarrhea, or alternation between both)

It is specifically designed to target the hypermotility and spasms of the colon that are central to the pain and discomfort experienced in IBS. It is not intended for the treatment of other gastrointestinal conditions like inflammatory bowel disease (IBD) or infectious colitis unless specifically advised by a physician.

Dosage and direction

The standard dosage for adults and adolescents over 12 years of age is one 135 mg tablet three times daily, preferably taken 20 minutes before meals.

The tablet should be swallowed whole with a glass of water; it should not be chewed or crushed. It is important to follow the dosage regimen prescribed by your doctor, as they may adjust it based on your individual response and symptom severity. Symptomatic improvement is often noticed within a few days to a week of starting treatment. Do not exceed the recommended dose.

Precautions

• A definitive diagnosis of Irritable Bowel Syndrome should be established by a physician before commencing treatment to rule out other more serious pathologies.
• Use with caution in patients with a known hypersensitivity to other medications.
• While not anticholinergic, patients should be monitored for any unusual reactions, especially during the initial phase of treatment.
• The safety and efficacy in children under the age of 12 years have not been established; therefore, its use in this population is not recommended.
• Patients should be advised that if symptoms worsen or do not improve after two weeks of therapy, they should consult their doctor for a re-evaluation.

Contraindications

Colospa is contraindicated in patients with:

• Known hypersensitivity to mebeverine hydrochloride or any of the excipients in the formulation.
• Paralytic ileus (a condition where the intestines are paralyzed).
• Severe hepatic impairment, due to the need for hepatic metabolism (use is not recommended).

Possible side effect

Colospa is generally well-tolerated. However, like all medicines, it can cause side effects, although not everybody gets them. Reported side effects are typically mild and transient.

• Common (may affect up to 1 in 10 people): Dizziness.
• Uncommon (may affect up to 1 in 100 people): Heartburn, nausea, constipation, diarrhea, skin rash, urticaria (hives).
• Rare (may affect up to 1 in 1,000 people): Angioedema (swelling of the face, lips, tongue, or throat).

If any side effects become severe or if you notice any side effects not listed here, please inform your doctor or pharmacist.

Drug interaction

Formal interaction studies have not been performed. However, as with any medication, the potential for interaction exists.

• No clinically significant pharmacokinetic interactions have been reported.
• Due to its direct action on smooth muscle, it is theoretically possible that Colospa could enhance the effects of other drugs that affect muscle tone.
• Always inform your doctor or pharmacist about all the medicines you are taking, including prescription, over-the-counter, and herbal products.

Missed dose

If you forget to take a dose of Colospa, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

Overdose

There are no specific reports of overdose with mebeverine. Given its pharmacological profile and high safety margin, significant toxic effects are unlikely. Symptoms of overdose would be expected to be an extension of its known side effects, such as dizziness or gastrointestinal disturbances. In case of suspected overdose, seek immediate medical attention or contact a Poison Control Center. Treatment should be symptomatic and supportive.

Storage

• Store below 30°C (86°F).
• Keep the tablets in the original blister pack or container to protect them from moisture and light.
• Keep out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the carton and blister after “EXP”. The expiry date refers to the last day of that month.
• Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on the product’s Summary of Product Characteristics (SmPC) and may not be exhaustive or fully updated.

Reviews

“Colospa has been a game-changer for managing my IBS cramps. The relief is focused and doesn’t leave me feeling drowsy or out of sorts like previous medications I’ve tried.” – Verified Patient

“As a gastroenterologist, I find Colospa to be a reliable first-line option for my patients with spasm-predominant IBS. Its targeted mechanism and lack of anticholinergic effects make it suitable for a wide patient demographic.” – Dr. A. Sharma, MD

“It took about a week to feel the full effect, but the reduction in daily bloating and pain has significantly improved my ability to work and socialize without constant anxiety.” – Verified Patient