Cialis: Restore Confidence with Long-Lasting Erectile Function
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| Product dosage: 2.5mg | |||
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Synonyms | |||
Similar products
Cialis (tadalafil) is a prescription phosphodiesterase type 5 (PDE5) inhibitor specifically formulated for the treatment of erectile dysfunction (ED). It works by increasing blood flow to the penis, facilitating an erection when sexual stimulation occurs. Unlike shorter-acting alternatives, its unique pharmacokinetic profile offers both on-demand and once-daily dosing flexibility, providing patients with sustained therapeutic efficacy and reduced planning anxiety. This medication represents a significant advancement in sexual medicine, offering a reliable option for men seeking to regain sexual spontaneity and improve intimate relationships.
Features
- Active Ingredient: Tadalafil
- Available Strengths: 2.5 mg, 5 mg, 10 mg, 20 mg tablets
- Mechanism of Action: Selective inhibition of phosphodiesterase type 5 (PDE5)
- Onset of Action: As early as 30 minutes post-administration
- Duration of Effect: Up to 36 hours with on-demand dosing
- Administration: Oral tablet, with or without food
- Manufacturer: Eli Lilly and Company
Benefits
- Provides a significantly extended window of opportunity for sexual activity compared to other ED medications
- Reduces performance anxiety through prolonged efficacy, allowing for more natural sexual spontaneity
- Available in daily low-dose formulation for continuous readiness without timing medication around sexual activity
- Effectively improves erectile function across various ED severities and etiologies
- Demonstrated improvement in sexual satisfaction and overall quality of life measures
- Also approved for treatment of benign prostatic hyperplasia (BPH) symptoms
Common use
Cialis is primarily prescribed for the treatment of erectile dysfunction in adult males. It is suitable for patients with ED of various origins, including vasculogenic, neurogenic, and psychogenic causes. The medication is also FDA-approved for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH) and for both ED and BPH when coexisting. Clinical studies have demonstrated efficacy in diverse patient populations, including those with diabetes mellitus and post-prostatectomy patients.
Dosage and direction
For erectile dysfunction (on-demand dosing):
- Recommended starting dose: 10 mg taken prior to anticipated sexual activity
- Dose may be increased to 20 mg or decreased to 5 mg based on efficacy and tolerability
- Take at least 30 minutes before sexual activity
- Maximum dosing frequency: once per day
For daily use:
- Recommended dose: 2.5 mg or 5 mg taken approximately the same time each day
- May be taken without regard to timing of sexual activity
- Requires daily adherence to maintain therapeutic effect
For benign prostatic hyperplasia:
- Recommended dose: 5 mg taken once daily at approximately the same time each day
Administration with high-fat meals may delay time to peak concentration but does not significantly affect overall exposure.
Precautions
- Cardiovascular status should be assessed prior to initiating therapy for erectile dysfunction
- Patients with pre-existing cardiovascular disease should be evaluated for exercise tolerance
- Use caution in patients with anatomical penile deformity or conditions that may predispose to priapism
- Consider potential for vasovagal response during sexual activity in patients with underlying cardiovascular risk
- Monitor for visual changes and discontinue if sudden vision loss occurs
- Use cautiously in patients with severe renal or hepatic impairment (dose adjustment required)
- Not recommended for use in patients with uncontrolled hypertension or hypotension
Contraindications
- Concomitant use of organic nitrates in any form (regularly or intermittently)
- Concomitant use with guanylate cyclase stimulators such as riociguat
- History of serious hypersensitivity reaction to tadalafil or any component of the formulation
- Patients with cardiac failure or coronary artery disease for whom sexual activity is not recommended
- Severe hepatic impairment (Child-Pugh Class C)
- Unstable angina or recent myocardial infarction (within 90 days)
Possible side effects
Common (≥2%):
- Headache (11-15%)
- Dyspepsia (4-10%)
- Back pain (3-6%)
- Myalgia (3-4%)
- Nasopharyngitis (3-4%)
- Flushing (3-4%)
- Limb pain (2-3%)
Less common:
- Dizziness (1-2%)
- Visual disturbances (including blurred vision, changes in color vision)
- Gastroesophageal reflux
- Palpitations
- Priapism (prolonged erection >4 hours) - requires immediate medical attention
Rare but serious:
- Sudden hearing loss
- Non-arteritic anterior ischemic optic neuropathy (NAION)
- Cardiovascular events (particularly in predisposed patients)
- Severe hypersensitivity reactions
Drug interaction
Contraindicated combinations:
- Nitrates (e.g., nitroglycerin, isosorbide mononitrate): Profound hypotension
- Riociguat: Additive hypotensive effects
Significant interactions requiring dose adjustment or monitoring:
- Alpha-blockers (e.g., doxazosin, tamsulosin): Additive blood pressure lowering
- Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Increase tadalafil exposure
- Antihypertensives: Potential additive hypotensive effects
- Alcohol: May increase hypotensive effects and orthostatic symptoms
Potential interactions:
- Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole)
- CYP3A4 inducers (e.g., rifampin, carbamazepine) may decrease tadalafil concentrations
Missed dose
For on-demand dosing: Take as needed before sexual activity. No scheduled dosing regimen exists for missed doses.
For daily dosing: Take the missed dose as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to make up for a missed dose. Maintain regular dosing schedule for continuous efficacy.
Overdose
Symptoms may include severe headache, dizziness, visual disturbances, nausea, vomiting, and marked hypotension. Management should include supportive measures with particular attention to maintaining blood pressure and symptomatic treatment. Hemodialysis is not expected to enhance elimination as tadalafil is highly protein-bound. In cases of severe hypotension, consider intravenous fluids and appropriate vasopressors with monitoring of vital signs.
Storage
Store at room temperature (20-25°C or 68-77°F) with excursions permitted between 15-30°C (59-86°F). Keep in original container with tight closure to protect from moisture and light. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Properly discard any unused medication.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Cialis is a prescription medication that should only be used under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with a healthcare professional before starting or changing any medication regimen. Do not share medication with others, even if they have similar symptoms. The full prescribing information should be reviewed before initiation of therapy.
Reviews
Clinical studies demonstrate significant improvement in erectile function across multiple validated instruments including the International Index of Erectile Function (IIEF). In randomized controlled trials, 81% of sexual attempts were successful with 20 mg on-demand dosing compared to 50% with placebo. Patient satisfaction surveys indicate improved confidence and relationship satisfaction. Daily dosing regimens show consistent efficacy with 80% of men reporting improved erections at 12 weeks. Real-world evidence supports maintained efficacy with long-term use in appropriate patient populations.