Ceftin (cefuroxime axetil) is a second-generation cephalosporin antibiotic indicated for the treatment of a wide range of bacterial infections. It functions by inhibiting bacterial cell wall synthesis, leading to bactericidal activity against susceptible organisms. This oral formulation combines broad-spectrum coverage with favorable pharmacokinetics, making it a valuable therapeutic option in both community and hospital settings. Healthcare providers prescribe Ceftin for its reliability in treating respiratory, skin, and urinary tract infections, among others.

Features

• Active ingredient: cefuroxime axetil
• Available in 250mg and 500mg tablet formulations
• Broad-spectrum activity against Gram-positive and Gram-negative bacteria
• Oral bioavailability enhanced by ester prodrug design
• Stable against many beta-lactamases
• BID (twice daily) dosing convenience

Benefits

• Effectively eradicates common bacterial pathogens responsible for respiratory and skin infections
• Reduces symptom severity and duration through rapid bactericidal action
• Minimizes risk of resistance development due to beta-lactamase stability
• Supports patient compliance with convenient twice-daily dosing
• Provides coverage against both Gram-positive and Gram-negative organisms
• Suitable for both adult and pediatric populations (with appropriate dosing)

Common use

Ceftin is commonly prescribed for bacterial pharyngitis/tonsillitis, acute bacterial otitis media, community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections. It is also used for the treatment of early Lyme disease and gonorrhea (uncomplicated). The medication demonstrates particular efficacy against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Escherichia coli.

Dosage and direction

Adults: Typical dosage ranges from 250mg to 500mg twice daily depending on infection severity and type. For most respiratory infections: 250-500mg BID. For skin infections: 250-500mg BID. For urinary tract infections: 125-250mg BID.
Pediatric patients: Dosing based on 10-15mg/kg twice daily (maximum 500mg daily).
Administration: Should be taken with food to enhance absorption. Tablets should be swallowed whole; do not crush or chew. Complete the full course of therapy even if symptoms improve earlier.

Precautions

Patients with renal impairment require dosage adjustment based on creatinine clearance. Use with caution in patients with history of gastrointestinal disease, particularly colitis. May result in overgrowth of nonsusceptible organisms. Prolonged use may result in fungal or bacterial superinfection. Caution advised in patients with history of penicillin allergy due to potential cross-reactivity. Monitor renal function during prolonged therapy.

Contraindications

Known hypersensitivity to cefuroxime or other cephalosporins. Patients with known anaphylactic reactions to penicillins should not receive cephalosporins due to cross-reactivity risk. Contraindicated in patients with history of severe gastrointestinal reactions to cephalosporins.

Possible side effect

Common adverse reactions include diarrhea (3-7%), nausea/vomiting (2-5%), abdominal pain, headache, and dizziness. Less frequent side effects may include transient elevation of liver enzymes, eosinophilia, positive Coombs test, vaginitis, and rash. Serious but rare side effects include pseudomembranous colitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis.

Drug interaction

Probenecid may inhibit renal excretion of cefuroxime, increasing serum concentrations. Concurrent use with potent diuretics may increase risk of nephrotoxicity. May reduce efficacy of oral contraceptives; recommend additional contraceptive methods. False-positive reactions for glucose in urine may occur with copper reduction tests.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed dose. Maintain regular dosing schedule to ensure consistent antibiotic levels.

Overdose

Symptoms may include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Treatment is supportive with gastric lavage if recently ingested. Hemodialysis may enhance elimination of cefuroxime. Monitor renal function and provide symptomatic treatment.

Storage

Store at room temperature (15-30°C or 59-86°F) in original container. Protect from moisture and light. Keep out of reach of children. Do not use after expiration date printed on packaging.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Ceftin is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Always follow your healthcare provider’s instructions regarding dosage and administration. Report any adverse reactions to your physician immediately.

Reviews

Clinical studies demonstrate Ceftin’s efficacy with success rates of 85-95% for approved indications. Physicians report good tolerability and effectiveness in community practice. Patients generally report satisfactory outcomes with complete resolution of infections when taken as directed. The twice-daily dosing regimen is frequently cited as advantageous for adherence compared to more frequent dosing schedules.