Aygestin (norethindrone) is a prescription progestin medication used to treat a range of gynecological and hormonal conditions. As a synthetic form of the natural hormone progesterone, it provides targeted hormonal regulation, offering a well-established option for managing abnormal uterine bleeding, amenorrhea, and endometriosis. Its mechanism of action works by altering the uterine lining and suppressing ovulation, making it a versatile tool in both therapeutic and diagnostic contexts. Healthcare providers rely on its predictable pharmacokinetics and decades of clinical use when designing individualized treatment plans.

Features

• Active ingredient: Norethindrone (5 mg per tablet)
• Form: Oral tablet
• Hormonal class: Synthetic progestin
• Prescription-only medication
• Available in blister packs of 30 tablets
• FDA-approved for specific gynecological indications

Benefits

• Effectively manages abnormal uterine bleeding by stabilizing the endometrium
• Provides relief from endometriosis-associated pain through hormonal suppression
• Restores menstrual cycles in cases of secondary amenorrhea
• Offers a diagnostic tool for evaluating estrogen production and endometrial responsiveness
• May be used as part of hormone replacement therapy (HRT) regimens
• Well-characterized safety profile with extensive clinical history

Common use

Aygestin is primarily prescribed for the treatment of abnormal uterine bleeding due to hormonal imbalance, secondary amenorrhea, and endometriosis. It is also used off-label for endometrial hyperplasia prevention, menstrual cycle regulation, and as part of hormone therapy protocols. In some cases, it serves as a diagnostic agent to assess estrogen status when administered as a progestin challenge test.

Dosage and direction

Dosage varies significantly based on indication and individual patient factors. For abnormal uterine bleeding: 2.5–10 mg daily for 5–10 days during the second half of the menstrual cycle. For endometriosis: 5 mg daily for two weeks, increasing by 2.5 mg daily every two weeks until 15 mg daily is reached, maintained for 6–9 months. For amenorrhea: 2.5–10 mg daily for 5–10 days. Tablets should be taken at the same time each day, with or without food. Always follow the specific dosing regimen prescribed by your healthcare provider.

Precautions

Patients should undergo thorough medical evaluation before starting Aygestin. Regular monitoring of blood pressure, liver function, and cardiovascular status is recommended. Use with caution in patients with depression, epilepsy, migraine, asthma, or cardiac dysfunction. May cause fluid retention; use carefully in patients with conditions that might be aggravated by fluid retention such as epilepsy, migraine, asthma, or cardiac or renal dysfunction. Long-term use may decrease bone mineral density; consider calcium and vitamin D supplementation.

Contraindications

Aygestin is contraindicated in patients with known hypersensitivity to norethindrone or any component of the formulation; undiagnosed abnormal genital bleeding; known or suspected pregnancy; current or history of thromboembolic disorders; liver dysfunction or disease; known or suspected hormone-dependent neoplasia; and missed abortion.

Possible side effects

Common side effects include nausea, headache, dizziness, breast tenderness, fluid retention, weight changes, and breakthrough bleeding. Less frequently reported effects include mood changes, insomnia, fatigue, acne, hirsutism, and changes in libido. Serious but rare adverse effects include thromboembolic events, hepatic adenomas, jaundice, and depression. Most side effects are dose-dependent and often diminish with continued use.

Drug interaction

Aygestin may interact with drugs that induce hepatic enzymes including rifampin, phenytoin, carbamazepine, and St. John’s wort, potentially reducing its effectiveness. Concurrent use with corticosteroids may enhance their effects. May interfere with the metabolism of cyclosporine. Anticoagulant effects may be altered when used with warfarin. Insulin requirements may change in diabetic patients. Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one. Consistent timing is important for maintaining stable hormone levels. If multiple doses are missed, breakthrough bleeding may occur. Contact your healthcare provider for specific guidance based on your treatment regimen.

Overdose

No serious adverse effects have been reported following acute overdose. Symptoms may include nausea, vomiting, and drowsiness. There is no specific antidote; treatment should be symptomatic and supportive. In cases of massive overdose, gastric lavage may be considered. Medical attention should be sought if concerning symptoms develop or if large quantities are ingested.

Storage

Store at room temperature (20–25°C or 68–77°F) in the original container. Protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly discard any unused medication according to FDA guidelines or through a drug take-back program.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Aygestin is a prescription medication that should only be used under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with your healthcare professional for diagnosis and treatment recommendations tailored to your specific medical condition.

Reviews

Clinical studies and patient reports generally indicate satisfactory outcomes with Aygestin when used appropriately for indicated conditions. Many patients report effective control of abnormal bleeding and reduction in endometriosis symptoms. Some note the adjustment period may involve temporary side effects that often resolve with continued use. Healthcare providers appreciate its established efficacy profile and predictable response patterns. Individual experiences vary based on condition severity, dosage, and personal physiology.