Artvigil: Enhance Wakefulness and Cognitive Performance
| Product dosage: 150 mg | |||
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Synonyms | |||
Artvigil is a prescription medication containing armodafinil, the R-enantiomer of modafinil, designed to promote wakefulness in individuals experiencing excessive sleepiness due to narcolepsy, obstructive sleep apnea, or shift work sleep disorder. It functions as a eugeroic, or wakefulness-promoting agent, by altering the natural chemicals (neurotransmitters) in the brain area that controls sleep and wakefulness. Unlike traditional stimulants, Artvigil offers a smoother, more sustained alertness with a lower potential for abuse, making it a valuable tool in managing sleep-wake cycle disruptions under medical supervision. Its mechanism provides a focused state of wakefulness without the jitteriness or severe crash associated with amphetamine-based compounds.
Features
- Active ingredient: Armodafinil (150 mg per tablet)
- Pharmacological class: Eugeroic (wakefulness-promoting agent)
- Onset of action: Typically within 1-2 hours post-administration
- Duration of effect: Up to 12-15 hours
- Bioavailability: Approximately 80% when taken orally
- Half-life: ~15 hours
- Excretion: Primarily renal, with some fecal elimination
- Formulation: Oral tablet, film-coated for ease of swallowing
Benefits
- Promotes prolonged wakefulness and reduces excessive daytime sleepiness, enabling improved daytime functioning for individuals with sleep disorders.
- Enhances cognitive functions such as memory, focus, and executive function, supporting productivity in demanding professional or academic settings.
- Offers a favorable side effect profile compared to traditional stimulants, with reduced risk of euphoria, dependency, or significant cardiovascular strain.
- Helps normalize the sleep-wake cycle in shift workers, facilitating adaptation to non-traditional work hours and improving overall job performance and safety.
- May improve quality of life by reducing the social and occupational impairment associated with chronic sleep conditions.
- Does not generally require dose escalation for sustained efficacy, supporting long-term use under medical guidance.
Common use
Artvigil is primarily indicated for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA) — particularly in cases where primary treatments for OSA (like CPAP) do not fully resolve daytime sleepiness — and shift work sleep disorder (SWSD). In clinical practice, it is also sometimes used off-label under specialist supervision for attention deficit hyperactivity disorder (ADHD), fatigue related to medical conditions such as multiple sclerosis or depression, and as cognitive enhancement in cases where alertness and concentration are critically required. It is not a substitute for healthy sleep hygiene and should be integrated into a comprehensive management plan that addresses underlying causes of sleep disruption.
Dosage and direction
The standard recommended dose of Artvigil is 150 mg taken orally once daily in the morning for narcolepsy or OSA, or approximately one hour prior to the start of a work shift for SWSD. It should be taken with or without food, though a high-fat meal may delay absorption. Dosage adjustments may be necessary in patients with severe hepatic impairment, where a reduced dose of 50–100 mg is advised. It is not recommended for use in patients with severe renal impairment. The tablet should be swallowed whole with water and not crushed, chewed, or split. Patients should avoid taking the medication late in the day to prevent interference with nighttime sleep.
Precautions
Patients should be advised to use caution when engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how Artvigil affects them. It is important to disclose any history of mental health conditions (e.g., depression, anxiety, psychosis), cardiovascular issues, liver or kidney disease, or substance abuse to the prescribing physician. Artvigil may reduce the effectiveness of hormonal contraceptives; alternative or additional non-hormonal methods of contraception should be used during and for one month after treatment. Regular monitoring of blood pressure and heart rate is recommended during treatment. Alcohol should be avoided, as it may alter the effects of the medication.
Contraindications
Artvigil is contraindicated in patients with a known hypersensitivity to armodafinil, modafinil, or any inactive ingredients in the formulation. It should not be used in individuals with a history of symptomatic cardiovascular disease such as left ventricular hypertrophy, mitral valve prolapse, chest pain, arrhythmias, or recent myocardial infarction. Use is also contraindicated in those with a history of psychosis or severe anxiety. It is not recommended during pregnancy or breastfeeding due to insufficient safety data. Artvigil is not approved for use in pediatric patients.
Possible side effect
Common side effects (≥5%) may include headache, nausea, dizziness, insomnia, anxiety, dry mouth, and diarrhea. Less frequently (1–5%), patients may experience nervousness, palpitations, increased heart rate, hypertension, decreased appetite, or rash. Rare but serious adverse effects include Stevens-Johnson Syndrome, angioedema, multiorgan hypersensitivity reactions, psychiatric symptoms such as depression, hallucinations, or suicidal ideation, and cardiovascular events. Any signs of severe skin reaction, allergic response, or psychiatric changes should prompt immediate discontinuation and medical attention.
Drug interaction
Artvigil is a moderate inducer of CYP3A4/5 and may reduce the plasma concentrations of drugs metabolized by this enzyme, such as cyclosporine, ethinyl estradiol, midazolam, triazolam, and certain statins. Conversely, strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) may increase armodafinil levels. It may also interact with drugs that affect serotonin (e.g., SSRIs, SNRIs, MAOIs), potentially increasing the risk of serotonin syndrome. Concomitant use with other CNS stimulants or depressants may amplify or diminish effects. A thorough review of the patient’s medication list is essential before prescribing.
Missed dose
If a dose is missed, it should be taken as soon as possible on the same day. However, if it is late in the day or near bedtime, the missed dose should be skipped to avoid insomnia. Doubling the dose to make up for a missed one is not recommended.
Overdose
Symptoms of overdose may include insomnia, restlessness, confusion, agitation, anxiety, tachycardia, hypertension, hallucinations, or gastrointestinal distress. In cases of suspected overdose, seek immediate medical attention. Treatment is symptomatic and supportive; there is no specific antidote. Hemodialysis is not expected to enhance elimination significantly.
Storage
Store at room temperature (20–25°C or 68–77°F), in a dry place, protected from light and moisture. Keep the medication in its original container, tightly closed, and out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here. Artvigil is a prescription medication and should be used only under the supervision of a licensed healthcare professional.
Reviews
“After being diagnosed with shift work sleep disorder, Artvigil has been a game-changer. I no longer struggle to stay alert during night shifts, and I’ve noticed a significant improvement in my concentration. The effect is smooth—no jitters or crash.” — Mark T., 42, Nurse
“I’ve tried other wakefulness agents, but Artvigil offers a more consistent and prolonged effect. It has greatly improved my productivity at work without interfering with my sleep when taken as directed.” — Lisa R., 38, Software Developer
“As someone with narcolepsy, Artvigil has restored a sense of normalcy to my life. I feel awake and engaged throughout the day. The only side effect I experienced was a mild headache during the first week, which subsided.” — James K., 50, Teacher
“My doctor prescribed Artvigil for residual sleepiness despite CPAP therapy. It complements my treatment well. I appreciate that it doesn’t make me feel ‘wired,’ just alert and focused.” — Sarah L., 45, Account Manager
“I use Artvigil for off-label cognitive support during exam preparations. It helps me maintain long study sessions with clarity. However, I ensure I use it sparingly and under medical guidance to avoid dependency.” — Daniel P., 24, Graduate Student