Advanced Retinoid Gel for Professional-Grade Skin Renewal
| Product dosage: 20g | |||
|---|---|---|---|
| Package (num) | Per tube | Price | Buy |
| 2 | $28.38 | $56.76 (0%) | 🛒 Add to cart |
| 3 | $24.94 | $85.14 $74.82 (12%) | 🛒 Add to cart |
| 4 | $22.36 | $113.52 $89.44 (21%) | 🛒 Add to cart |
| 5 | $19.78 | $141.90 $98.90 (30%) | 🛒 Add to cart |
| 6 | $17.20 | $170.28 $103.20 (39%) | 🛒 Add to cart |
| 7 | $15.97 | $198.66 $111.80 (44%) | 🛒 Add to cart |
| 8 | $15.16 | $227.04 $121.26 (47%) | 🛒 Add to cart |
| 9 | $14.24 | $255.42 $128.14 (50%) | 🛒 Add to cart |
| 10 | $13.07
Best per tube | $283.80 $130.72 (54%) | 🛒 Add to cart |
Synonyms | |||
Retin-A Gel (tretinoin 0.1%) is a prescription-strength topical retinoid formulated to address moderate to severe acne and visible photodamage. Its microsphere-encapsulated delivery system ensures targeted, sustained release of tretinoin—the gold-standard retinoid—enhancing epidermal penetration while minimizing potential irritation. Clinically proven to unclog pores, accelerate cellular turnover, and stimulate collagen production, this gel formulation represents a cornerstone in evidence-based dermatological therapy for patients seeking medical-grade results.
Features
- Pharmaceutical-grade tretinoin 0.1% in alcohol-based gel vehicle
- Microencapsulation technology for controlled active ingredient release
- Oil-free, non-comedogenic formulation
- pH-balanced to match skin’s natural acidity (pH ~5.5)
- Rapid-drying, non-greasy texture suitable for oily and combination skin types
- Preservative system including butylated hydroxytoluene (BHT) for stability
- Airless pump packaging to maintain ingredient potency and prevent oxidation
Benefits
- Significantly reduces inflammatory and non-inflammatory acne lesions through comprehensive follicular cleansing
- Diminishes appearance of fine lines, wrinkles, and photodamage by stimulating Type I and III collagen synthesis
- Improves skin texture and tone through enhanced desquamation and epidermal remodeling
- Prevents microcomedone formation—the precursor lesion to all acne manifestations
- Fades post-inflammatory hyperpigmentation by accelerating melanin dispersion and keratinocyte turnover
- Creates long-term improvements in skin health through retinoid-mediated gene expression changes
Common use
This retinoid gel is primarily indicated for the treatment of acne vulgaris grades II-IV, characterized by comedones, papules, pustules, and occasional nodules. Dermatologists frequently prescribe it for off-label use in photoaging management, including improvement of fine wrinkles, mottled hyperpigmentation, and rough skin texture. The gel formulation is particularly suitable for patients with oily skin who may experience comedogenicity from cream-based retinoids. Many practitioners incorporate it into comprehensive acne protocols alongside benzoyl peroxide, antibiotics, or oral medications, though not applied simultaneously.
Dosage and direction
Apply a pea-sized amount to entire affected area once daily, preferably in the evening. Begin with application every second or third night for the first 2-3 weeks to assess tolerance. Gently cleanse skin with mild, non-abrasive cleanser and pat dry before application. Wait 20-30 minutes after washing to ensure complete skin dryness, as application to damp skin may increase penetration and irritation risk. Spread thinly and evenly, avoiding eyes, lips, nasolabial folds, and mucous membranes. Morning application is not recommended due to tretinoin’s photosensitizing properties. Treatment response typically becomes apparent after 2-3 weeks, with significant improvement occurring over 8-12 weeks of continuous therapy.
Precautions
Discontinue use if hypersensitivity reactions occur, including severe erythema, edema, blistering, or crusting. Sun exposure should be minimized during treatment, and broad-spectrum sunscreen (SPF 30 or higher) must be used daily, even on cloudy days. Weather extremes, such as wind or cold, may increase irritation potential. Avoid concomitant use of abrasive cleansers, astringents, and other potentially irritating topical products (including alcohol-based toners and exfoliants). Not recommended for use immediately after hair removal procedures (waxing, laser, electrolysis). Contact with eyes, mouth, angles of the nose, and mucous membranes must be avoided. Patients with eczema or seborrheic dermatitis may experience exacerbated symptoms.
Contraindications
This product is contraindicated in individuals with known hypersensitivity to tretinoin or any component of the formulation. Should not be used during pregnancy (Category C—animal studies have shown adverse effects, no adequate human studies) or by women attempting to conceive. Breastfeeding mothers should avoid application to chest area and consult healthcare provider. Not recommended for patients with sunburn, eczema, or other inflammatory skin conditions at application sites. Contraindicated in patients with personal or family history of cutaneous lupus erythematosus or porphyria.
Possible side effects
Most patients experience some degree of retinoid dermatitis during initial treatment phases, characterized by erythema, peeling, dryness, and stinging/burning sensation—often described as the “retinoid reaction.” These effects typically peak at 2-3 weeks and gradually diminish with continued use. Other potential side effects include photosensitivity, temporary hyperpigmentation or hypopigmentation, and skin irritation. Rare reports include blistering, crusting, and contact allergy. Paradoxical acne flare may occur during initial weeks as microcomedones purge. Most reactions are dose-dependent and manageable with application frequency adjustment.
Drug interaction
Concurrent use with other topical acne medications (particularly benzoyl peroxide, salicylic acid, or azelaic acid) may increase irritation potential—staggered application (AM/PM) is recommended. Avoid combination with topical antibiotics unless directed by physician, as some formulations may inactivate tretinoin. Photosensitizing medications (tetracyclines, fluoroquinolones, sulfonamides, phenothiazines) may compound photosensitivity risk. Caution advised with topical corticosteroids (may alter skin barrier function) and keratolytic agents (may enhance penetration unpredictably). Oral retinoids are absolutely contraindicated during therapy.
Missed dose
Apply as soon as remembered, unless it is nearly time for the next scheduled application. Do not double application to compensate for missed dose. Resume regular application schedule with next dose. Consistent application is important for therapeutic efficacy, but occasional missed doses are not clinically significant given tretinoin’s mechanism of action through retinoid nuclear receptors with prolonged effects.
Overdose
Topical overdose may manifest as severe erythema, peeling, discomfort, or edema. Treatment involves immediate discontinuation until skin integrity恢复正常. Supportive care includes cool compresses, bland emollients, and temporary use of mild topical corticosteroids if inflammation is severe. Oral overdose is unlikely with topical formulation but would require symptomatic management. Accidental ingestion should prompt immediate medical attention—potential symptoms include headache, dizziness, and gastrointestinal upset.
Storage
Store at controlled room temperature (20-25°C or 68-77°F). Avoid freezing or exposure to excessive heat (above 40°C/104°F). Keep container tightly closed and protected from light. Do not store in bathroom where moisture and temperature fluctuations may degrade active ingredient. Keep out of reach of children and pets. Discard 3 months after opening or by expiration date, whichever comes first.
Disclaimer
This product is available by prescription only. The information provided does not replace professional medical advice. Consult a qualified healthcare provider for diagnosis and appropriate treatment options. Individual results may vary based on skin type, condition severity, and adherence to treatment protocol. Not evaluated by FDA for all claimed benefits. Safety and efficacy in children under 12 have not been established.
Reviews
“After 16 weeks of consistent use, my moderate acne has reduced by approximately 80%. The initial peeling phase was challenging but manageable with moisturizer adjustment. Significant improvement in skin texture and post-acne marks.” — Verified patient, 28
“As a dermatologist, I prescribe this formulation particularly for oily-skinned acne patients who haven’t responded to weaker retinoids. The microsphere technology provides excellent efficacy with relatively manageable irritation profile compared to some conventional gels.” — Board-certified dermatologist
“Noticeable improvement in fine lines around eyes and mouth after 6 months. Sun protection is absolutely non-negotiable—learned this the hard way with minor pigmentation issues early in treatment.” — Verified patient, 42
“The gel vehicle makes it ideal for combination skin. Unlike cream formulations that sometimes cause closed comedones, this maintains clarity while delivering active ingredient effectively.” — Esthetician, 36