Gyne-Lotrimin is a leading over-the-counter antifungal medication specifically formulated to treat vulvovaginal candidiasis. Its active ingredient, clotrimazole, targets the cell membranes of Candida albicans and other susceptible fungi, disrupting their integrity and leading to fungal cell death. This topical cream provides symptomatic relief from itching, burning, and discharge associated with yeast infections, with many users reporting improvement within just a few days. Trusted by healthcare professionals and available without a prescription, it offers a convenient, effective solution for uncomplicated cases.

Features

• Contains 2% clotrimazole as the active antifungal agent
• Available in 1 oz (28 g) tube with measured-dose applicator
• Topical cream formulation for localized treatment
• Designed for intravaginal and external vulvar application
• Seven-day treatment course for complete infection clearance
• Hypoallergenic formulation, fragrance-free and dye-free
• Clinically tested and FDA-approved for OTC use
• Water-soluble base for easy application and minimal residue

Benefits

• Rapid relief from itching, burning, and irritation within first few applications
• Effectively eliminates Candida albicans, the primary causative organism in 90% of yeast infections
• Prevents recurrence by completing full treatment course to eradicate fungal colonization
• Minimizes systemic absorption with localized topical action, reducing risk of side effects
• Convenient self-administration with included applicator for precise dosage delivery
• Cost-effective alternative to prescription antifungals with comparable efficacy for uncomplicated cases

Common use

Gyne-Lotrimin is indicated for the treatment of vulvovaginal candidiasis (vaginal yeast infections) caused by susceptible strains of Candida species. Typical symptoms include vaginal itching, burning, soreness, irritation, and a thick, white, odorless discharge resembling cottage cheese. It is appropriate for first-time occurrences and recurrent infections in non-pregnant, immunocompetent individuals. The product is most effective when used at the earliest signs of infection and is suitable for women aged 12 and older.

Dosage and direction

Administer one applicatorful (approximately 5 grams) of Gyne-Lotrimin cream intravaginally once daily at bedtime for 7 consecutive days. For external vulvar symptoms, apply a thin layer to affected areas twice daily, morning and evening. Wash hands before and after application. To use: remove cap from tube, attach applicator to tube, squeeze cream into applicator until plunger stops, detach applicator, lie on back with knees bent, insert applicator gently into vagina, and push plunger to deposit cream. Clean applicator with mild soap and water after each use.

Precautions

• For vaginal use only; avoid contact with eyes
• Do not use if allergic to clotrimazole or any inactive ingredients
• Not for use during pregnancy unless directed by physician (typically second and third trimester only under medical supervision)
• Discontinue use if irritation or sensitivity develops
• Do not use with diaphragm or condoms as cream may damage latex
• Consult healthcare provider if symptoms persist beyond 7 days or worsen during treatment
• Not intended for systemic or oral fungal infections
• Store at room temperature away from excessive heat or moisture

Contraindications

Gyne-Lotrimin is contraindicated in patients with known hypersensitivity to clotrimazole, other imidazole antifungals, or any component of the formulation. It should not be used by individuals with fever, abdominal pain, foul-smelling discharge, or history of recurrent infections (more than 4 per year) without medical evaluation to rule out mixed infections or resistant organisms. Not recommended for children under 12 years or for treatment of non-candidal vaginitis.

Possible side effects

Most users experience minimal side effects, though localized reactions may include:

• Mild burning or irritation upon application (usually transient)
• Itching or redness at application site
• Skin rash or hives (indicative of allergic reaction)
• Vaginal discomfort, cramping, or pain
• Increased urinary frequency
• Rare cases of abdominal discomfort or headache

Drug interaction

No significant drug interactions have been reported with topical clotrimazole. However, concurrent use with other vaginal products may alter efficacy or increase irritation. Avoid using with other antifungal agents, corticosteroid creams, or vaginal douches unless directed by healthcare provider. The water-soluble base may interact with latex contraceptives, reducing their effectiveness—consider alternative barrier methods during treatment.

Missed dose

Apply the missed dose as soon as remembered, unless it is almost time for the next scheduled application. Do not double the dose to make up for a missed application. Continue with the regular dosing schedule. Maintaining consistent daily application is important for complete eradication of the infection, but a single missed dose is unlikely to significantly impact overall efficacy if the treatment course is completed.

Overdose

Topical overdose is unlikely due to minimal systemic absorption. Excessive application may cause increased local irritation, burning, or redness. If accidentally ingested, seek medical attention immediately—though systemic effects are rare, gastrointestinal upset may occur. Treatment is supportive; there is no specific antidote for clotrimazole overdose.

Storage

Store at room temperature between 15-30°C (59-86°F). Keep tube tightly closed when not in use. Do not freeze. Keep out of reach of children and pets. Discard any unused product after completing treatment course. Do not use if expiration date has passed or if product shows signs of separation, discoloration, or unusual odor.

Disclaimer

This product is for self-treatment of vaginal yeast infections only when the diagnosis has been previously confirmed by a healthcare provider. Consult a physician if this is your first yeast infection, if you are pregnant, diabetic, immunocompromised, or if symptoms persist after 7 days or recur within 2 months. Seek immediate medical attention if you develop fever, chills, abdominal pain, or foul-smelling discharge, as these may indicate a more serious condition.

Reviews

Clinical studies demonstrate complete symptomatic relief in 80-90% of patients after 7-day course. User reviews consistently report rapid relief from itching and burning, with many noting improvement within 48 hours. Healthcare professionals recommend it as first-line OTC treatment for uncomplicated vulvovaginal candidiasis. Common praises include ease of use, effectiveness, and minimal side effects compared to oral antifungals. Some users note messiness of cream formulation but find results justify the inconvenience.