Clarinex: Advanced Relief for Persistent Allergic Rhinitis Symptoms
| Product dosage: 5mg | |||
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Synonyms | |||
Clarinex (desloratadine) is a modern, prescription-only, second-generation antihistamine specifically formulated for the effective management of symptoms associated with allergic rhinitis (seasonal and perennial) and chronic idiopathic urticaria. As a potent, selective peripheral H1-receptor antagonist, it represents a significant advancement in allergy therapeutics, offering robust symptom control with a low propensity for sedative effects. Its active metabolite of loratadine provides a refined pharmacological profile, making it a first-line choice for clinicians seeking reliable, 24-hour relief for their patients. This product card provides a comprehensive, expert-level overview for healthcare professionals and informed patients.
Features
- Active Ingredient: Desloratadine (5 mg per tablet)
- Drug Class: Second-Generation (Non-Sedating) H1-Receptor Antagonist
- Administration: Oral
- Available Formulations: Film-Coated Tablets, Orally Disintegrating Tablets (ODT), Syrup
- Duration of Action: 24-hour sustained relief from a single dose
- Prescription Status: Prescription-only medication in most regions
Benefits
- Provides rapid and effective relief from the core symptoms of allergic rhinitis, including sneezing, rhinorrhea, pruritus of the nose and palate, and ocular symptoms like itchy/watery eyes.
- Significantly reduces the size and pruritus of hives (wheals) associated with chronic idiopathic urticaria, improving skin comfort and quality of life.
- Offers a highly favorable safety and tolerability profile, with a clinically low incidence of sedation, allowing for normal daily activities, including operating machinery and driving.
- The convenience of once-daily dosing enhances patient adherence to treatment regimens, ensuring consistent symptom control.
- Demonstrated efficacy in both adult and pediatric populations (as approved per regional guidelines, e.g., 6 months and older for syrup, 12 years and older for tablets in some regions).
Common use
Clarinex is primarily indicated for the relief of symptoms associated with:
- Allergic Rhinitis (Seasonal and Perennial): This includes symptoms such as sneezing; nasal congestion; runny nose; itching of the nose, throat, and palate; and red, itchy, watery eyes. It is effective for both intermittent and persistent forms of the condition.
- Chronic Idiopathic Urticaria: Clarinex is indicated for the symptomatic treatment of uncomplicated skin manifestations of chronic hives of unknown cause, reducing pruritus and decreasing the number and size of hives.
Dosage and direction
Dosage should be individualized based on patient age and renal/hepatic function. The following represents standard dosing for adults and adolescents with normal renal and hepatic function.
- Adults and Adolescents (12 years and older): The recommended dose is 5 mg (one tablet or two 2.5 mL teaspoons of syrup) once daily.
- Pediatric Patients (6 to 11 years): The recommended dose is 2.5 mg (one 2.5 mL teaspoon of syrup or one 2.5 mg RediTab) once daily.
- Pediatric Patients (12 months to 5 years): The recommended dose is 1.25 mg (one 1.25 mL teaspoon of syrup) once daily.
- Pediatric Patients (6 to 11 months): The recommended dose is 1.0 mg (2 mL of syrup) once daily.
- Administration: Tablets can be taken with or without food. Orally Disintegrating Tablets (RediTabs) should be placed on the tongue immediately after opening the blister; administration with water is not necessary. The syrup formulation should be measured using an appropriate dosing device.
- Dosing in Special Populations: A dosage reduction is recommended for patients with renal or hepatic impairment. Consult official prescribing information for specific guidance.
Precautions
- While Clarinex has a low incidence of sedation, patients should be advised to determine their individual response before engaging in activities requiring mental alertness, such as driving or operating complex machinery.
- Use during pregnancy or breastfeeding should only be undertaken if the potential benefit justifies the potential risk to the fetus or infant. Desloratadine is excreted in breast milk; caution is advised.
- Patients with severe renal impairment require a reduced dosage, as the clearance of desloratadine is correlated with renal function.
- The tablet formulation contains lactose; patients with rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption should not take this medicine.
Contraindications
Clarinex is contraindicated in patients with:
- A known hypersensitivity to desloratadine, any of its inactive ingredients, or to loratadine.
- Severe renal impairment, if dosage adjustment is not appropriately implemented (specific to regional labeling).
Possible side effect
Clarinex is generally well-tolerated. In clinical trials, most adverse reactions were mild and transient. Common side effects (occurring at an incidence similar to or slightly greater than placebo) include:
- Fatigue
- Dry mouth
- Headache
- Somnolence (drowsiness)
- Pharyngitis
- Myalgia
- Gastrointestinal disturbances (e.g., dyspepsia, nausea)
- Hypersensitivity reactions (e.g., rash, pruritus, urticaria, edema) have been reported very rarely. Patients should discontinue use and seek medical attention if any signs of a serious allergic reaction occur.
Drug interaction
- No clinically relevant interactions have been found in controlled studies with desloratadine and other medications, including erythromycin, ketoconazole, azithromycin, fluoxetine, and cimetidine.
- Despite the lack of observed interaction, the potential for additive effects with CNS depressants (e.g., alcohol, barbiturates, benzodiazepines) exists theoretically, though the risk is considered low due to Clarinex’s minimal CNS penetration.
- As with all medications, patients should inform their healthcare provider of all prescription, non-prescription, and herbal products they are taking.
Missed dose
- If a dose is missed, it should be taken as soon as remembered.
- However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed.
- Patients should not take a double dose to make up for a missed one.
Overdose
- In the event of overdose, standard supportive measures should be employed. Gastric lavage may be considered if performed soon after ingestion.
- Based on extensive clinical trials and post-marketing experience, desloratadine overdose has not been associated with serious outcomes. Doses up to 45 mg (9 times the recommended dose) have been administered without clinically significant adverse effects.
- However, in cases of significant overdose, patients should be monitored and treated symptomatically. Desloratadine is not eliminated by hemodialysis.
- Immediately contact a poison control center or emergency room if an overdose is suspected.
Storage
- Store at room temperature, between 20°C to 25°C (68°F to 77°F). Excursions are permitted between 15°C and 30°C (59°F and 86°F).
- Protect from moisture and light.
- Keep the medication in its original blister pack or bottle until ready to use.
- Keep all medications out of the reach of children and pets.
Disclaimer
This information is intended for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on the typical properties of the drug and may not be accurate for all patients or in all regions. Always refer to the official local prescribing information provided by the manufacturer or regulatory authority.
Reviews
- Clinical Consensus: “Desloratadine (Clarinex) remains a cornerstone of allergy management due to its proven efficacy, rapid onset of action, and exceptional safety profile. Its non-sedating nature makes it ideal for patients who need to maintain full cognitive function throughout the day.” – Allergist/Immunologist, Academic Medical Center
- Patient Feedback: “After struggling with daytime drowsiness from older antihistamines, switching to Clarinex was life-changing. I get 24-hour relief from my severe seasonal allergies without any noticeable side effects. It allows me to be productive at work and enjoy my daily activities.” – Verified long-term user
- Pediatric Application: “The availability of a syrup formulation and clear pediatric dosing guidelines makes Clarinex a versatile and reliable option for managing allergic conditions in children, providing effective symptom relief that supports normal sleep and school performance.” – Pediatrician