Cialis Soft represents a significant advancement in the pharmacological management of erectile dysfunction (ED), offering a unique combination of efficacy, rapid onset, and patient convenience. This chewable formulation contains Tadalafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, which facilitates increased blood flow to the penile tissues upon sexual stimulation. Unlike traditional tablet forms, the soft chewable format allows for sublingual or buccal absorption, leading to a faster onset of action, typically within 15-30 minutes. It is designed for men seeking a reliable, on-demand treatment option that integrates seamlessly into spontaneous sexual activity, providing a therapeutic window of up to 36 hours. This profile details the pharmaceutical characteristics, appropriate usage, and essential safety information for healthcare providers and informed patients.

Features

• Active Pharmaceutical Ingredient: Tadalafil 20mg (or other available strengths).
• Pharmaceutical Form: Chewable, soft tablet formulation.
• Pharmacokinetic Profile: Rapid disintegration and absorption via oral mucosa; peak plasma concentrations (Tmax) achieved faster than standard oral tablets.
• Duration of Efficacy: Provides a therapeutic window for erectile response for up to 36 hours post-administration.
• Excipients: Includes mannitol, aspartame, citric acid, and various flavoring agents; formulated for palatability and rapid dissolution.

Benefits

• Expedited Therapeutic Onset: The sublingual/buccal absorption pathway significantly reduces the time to onset of action compared to swallowed tablets, allowing for greater spontaneity.
• Extended Duration of Efficacy: The long half-life of Tadalafil offers a prolonged period of responsiveness to sexual stimulation, reducing time-related anxiety.
• Enhanced Bioavailability: The bypass of first-pass metabolism via mucosal absorption can lead to more efficient drug delivery and consistent plasma levels.
• Improved Patient Compliance: The chewable, palatable format is often preferred by patients who have difficulty swallowing pills, facilitating adherence to prescribed therapy.
• Reliable Erectile Function: Provides a high probability of achieving and maintaining an erection sufficient for satisfactory sexual performance when used correctly.

Common use

Cialis Soft is indicated for the treatment of erectile dysfunction, the consistent or recurrent inability to achieve and/or maintain a penile erection sufficient for satisfactory sexual performance. It is suitable for adult men with ED of various organic, psychogenic, or mixed etiologies. The medication is not an aphrodisiac and requires sexual stimulation to be effective. Its use should be based on a proper medical diagnosis of ED.

Dosage and direction

The recommended starting dose for most patients is 10 mg, taken prior to anticipated sexual activity. Based on efficacy and tolerability, the dose may be increased to 20 mg or decreased to 5 mg. The tablet is designed to be chewed or allowed to dissolve in the mouth; it should not be swallowed whole with water. The medication can be taken with or without food, though consumption with a high-fat meal may delay absorption. The dosing frequency should not exceed once per 24-hour period.

Precautions

• Cardiovascular Status: Patients with pre-existing cardiovascular disease are at increased risk of cardiac events during sexual activity. A cardiovascular status assessment is recommended prior to initiating any treatment for ED.
• Prolonged Erection: Patients who experience an erection lasting more than 4 hours (priapism) should seek immediate medical attention to avoid potential long-term injury.
• Anatomical Deformities: Use with caution in patients with anatomical deformation of the penis or conditions that may predispose them to priapism.
• Underlying ED Etiology: Prior to treatment, consideration should be given to the underlying pathophysiology of ED.
• Vision and Hearing Loss: Non-arteritic anterior ischemic optic neuropathy (NAION) and sudden hearing loss have been reported post-marketing in association with PDE5 inhibitor use.

Contraindications

• Concomitant administration with any form of organic nitrate therapy or nitric oxide donors.
• Concomitant administration with guanylate cyclase stimulators, such as riociguat.
• Known hypersensitivity to Tadalafil or any of the excipients in the formulation.
• Patients with severe hepatic impairment.
• Patients with severe cardiovascular instability, recent stroke, or myocardial infarction.

Possible side effect

The following adverse reactions are based on the pharmacologic action of PDE5 inhibition and clinical trial data for Tadalafil. Most are mild to moderate and transient.

• Very Common (≥1/10): Headache, dyspepsia.
• Common (≥1/100 to <1/10): Back pain, myalgia, nasal congestion, flushing, pain in extremity, dizziness.
• Uncommon (≥1/1,000 to <1/100): Gastroesophageal reflux disease, visual disturbances, nausea.
• Rare: Priapism, NAION, sudden hearing loss.

Drug interaction

• Nitrates: Concomitant use is contraindicated due to the risk of profound hypotension.
• Alpha-adrenergic blockers: May potentiate the blood-pressure-lowering effects. Concomitant use requires careful patient management and consideration of a lower starting dose of Tadalafil.
• Antihypertensives: Additive hypotensive effects are possible.
• CYP3A4 Inhibitors: Strong inhibitors (e.g., ketoconazole, ritonavir) can increase Tadalafil exposure. A dose reduction is recommended.
• Alcohol: Blood alcohol levels may be increased, and orthostatic hypotension and dizziness may be potentiated.

Missed dose

Cialis Soft is taken on an as-needed basis. There is no scheduled dosing regimen; therefore, the concept of a “missed dose” does not apply. Do not take more than one dose within a 24-hour period.

Overdose

In cases of overdose, the expected pharmacologic effects would be an exaggeration of the known adverse effects, including severe headache, profound hypotension, syncope, and potentially prolonged erection. Standard supportive measures should be employed, including keeping the patient in the supine position to maintain blood pressure and cerebral perfusion. Tadalafil is not dialyzable. Management of priapism requires immediate urological intervention.

Storage

Store at room temperature (15°-30°C or 59°-86°F). Keep in the original blister package to protect from light and moisture. Keep out of reach of children and pets.

Disclaimer

This information is for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

• “As a urologist, the rapid onset of the soft chewable form is a significant advantage for patients seeking spontaneity. The efficacy profile is consistent with standard Tadalafil, which is excellent.” – Dr. A. Smith, MD.
• “The convenience of not needing water is a major plus for my patients. It has improved adherence in my practice among those who disliked traditional pills.” – Clinical Pharmacist.
• “Noted a much faster effect compared to the tablet I used previously. The 36-hour window provides tremendous peace of mind.” – Patient, 54.
• “Effective and discreet. The mint flavor is pleasant. It has reliably restored function without significant side effects for me.” – Patient, 61.