Cialis Daily: Continuous Confidence for Erectile Dysfunction
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Synonyms | |||
Similar products
Cialis Daily (tadalafil) is a low-dose, prescription medication designed for daily use to manage erectile dysfunction (ED). Unlike on-demand treatments, it provides continuous therapeutic coverage, allowing for spontaneous sexual activity without the need for timing medication around anticipated intimacy. Its active ingredient, tadalafil, is a phosphodiesterase type 5 (PDE5) inhibitor that works by increasing blood flow to the penis upon sexual stimulation. This regimen is ideal for men who anticipate frequent sexual activity (e.g., twice or more per week) and prefer the convenience of not planning around a pill. It offers a steady-state plasma concentration, ensuring readiness is maintained around the clock.
Features
- Active Ingredient: Tadalafil (2.5 mg or 5 mg)
- Classification: Phosphodiesterase type 5 (PDE5) inhibitor
- Administration: Oral tablet, taken once daily
- Onset of Action: Effective within 24-36 hours of the first dose for daily regimen; optimal efficacy achieved after 5 days of consistent use
- Duration: Provides continuous therapeutic coverage with daily dosing
- Bioavailability: Approximately 36-42%
- Half-life: 17.5 hours (mean terminal half-life)
- Metabolism: Primarily hepatic, via CYP3A4
- Excretion: Mainly fecal (~61%) and renal (~36%)
Benefits
- Enables spontaneous sexual activity without the need to plan medication timing
- Maintains consistent erectile function support with daily dosing
- Reduces performance anxiety associated with scheduled ED treatments
- Suitable for frequent sexual activity (e.g., multiple times per week)
- May improve overall sexual satisfaction and relationship dynamics
- Low-dose formulation minimizes peak-trough drug level variations
Common use
Cialis Daily is prescribed for the treatment of erectile dysfunction, the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is particularly suitable for men in stable sexual relationships who engage in or desire frequent sexual activity. The daily dosing regimen is also sometimes used off-label for the treatment of benign prostatic hyperplasia (BPH) with concomitant ED, though specific BPH formulations exist. Patients should have a thorough medical evaluation to confirm the diagnosis of ED and rule out other underlying conditions before initiation.
Dosage and direction
The recommended starting dose for Cialis Daily is 2.5 mg taken orally once per day, at approximately the same time each day. Based on efficacy and tolerability, the dose may be increased to 5 mg once daily. The medication may be taken with or without food. Sexual activity may occur at any time after initiation, but optimal effect is achieved after taking the daily dose for at least 5-7 days to reach steady-state plasma concentrations. Do not take more than one tablet in 24 hours. The tablet should be swallowed whole with a glass of water; it should not be split, crushed, or chewed.
Precautions
- Prior to prescribing, assess cardiovascular status; sexual activity is not recommended for patients with cardiac conditions for whom sexual activity is inadvisable.
- Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie’s disease) or conditions predisposing to priapism (e.g., sickle cell anemia, multiple myeloma, leukemia).
- Caution advised in patients with bleeding disorders or active peptic ulceration.
- Not recommended for use in patients with severe hepatic impairment (Child-Pugh Class C); dose adjustment recommended for moderate impairment.
- Use with caution in patients with severe renal impairment (creatinine clearance <30 mL/min); daily dosing is not recommended in this population.
- May cause hypotension; caution in patients on antihypertensive therapy.
- Advise patients to avoid excessive alcohol consumption (may increase risk of orthostatic hypotension).
- Contains lactose; not suitable for patients with galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.
Contraindications
- Concomitant administration with any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors in any form.
- Concomitant administration with guanylate cyclase stimulators (e.g., riociguat).
- History of hypersensitivity to tadalafil or any excipient in the formulation.
- Patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION).
- Use in women, children, or adolescents under 18 years of age.
Possible side effect
The following adverse reactions have been reported with the use of tadalafil. Most are mild to moderate and transient.
- Very common (≥1/10): Headache, dyspepsia
- Common (≥1/100 to <1/10): Back pain, myalgia, nasal congestion, flushing, pain in extremity, dizziness
- Uncommon (≥1/1,000 to <1/100): Gastroesophageal reflux disease, nausea, vomiting, abdominal pain, visual disturbances (e.g., blurred vision, chromatopsia), tachycardia, palpitations, hypotension, syncope, rash, pruritus, urticaria, increased sweating
- Rare (≥1/10,000 to <1/1,000): Priapism (prolonged and painful erection lasting more than 4 hours), sudden hearing loss, NAION
- Frequency not known: Hypersensitivity reactions (including skin exfoliation, Stevens-Johnson syndrome), seizures, migraine
Drug interaction
- Nitrates: Concomitant use is contraindicated due to risk of profound hypotension.
- Alpha-blockers: Concomitant use can potentiate hypotensive effects; not recommended. If co-administration is necessary, initiate at the lowest possible dose and monitor blood pressure.
- Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir): Increase tadalafil exposure. For daily dosing, the maximum recommended dose is 2.5 mg when co-administered with a potent CYP3A4 inhibitor.
- Antihypertensives: May potentiate hypotensive effect.
- Alcohol: May increase hypotensive effects; patients should be cautioned about excessive intake.
- Other PDE5 inhibitors: Concomitant use is not recommended.
Missed dose
If a dose is missed, it should be taken as soon as remembered on the same day. If it is not remembered until the next day, the missed dose should be skipped, and the regular dosing schedule resumed. Do not take a double dose to make up for a missed one.
Overdose
In cases of suspected overdose, standard supportive measures should be employed. Tadalafil has been administered in single doses up to 500 mg; adverse events were similar to those seen at lower doses but with higher incidence. Hemodialysis is not expected to accelerate clearance as tadalafil is highly bound to plasma proteins and not significantly eliminated in urine.
Storage
Store in the original container at room temperature (15°C to 30°C). Keep the container tightly closed to protect from moisture and light. Keep out of reach and sight of children. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and before starting or changing any treatment regimen. Do not disregard professional medical advice or delay seeking it because of something you have read here. The prescriber should be familiar with the full prescribing information before initiating therapy.
Reviews
Clinical studies and patient reported outcomes consistently demonstrate high satisfaction rates with the Cialis Daily regimen. In pivotal trials, men reported improved erectile function scores, increased success rates for vaginal penetration, and high rates of satisfaction with the spontaneity afforded by daily dosing. Many users report a significant reduction in anxiety related to sexual performance timing. The side effect profile is generally well-tolerated, with most adverse events being mild and diminishing over time. Adherence to the daily regimen is high among motivated patients seeking uninterrupted treatment efficacy.